SynthesisNeurosurgical review2025
The association between systemic immune-inflammation index and the short-term functional outcome of patients with aneurysmal subarachnoid hemorrhage: a meta-analysis.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Systemic inflammation response index as an independent predictor of unfavorable prognosis and its application in risk stratification in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neuroscience · 2026Article
- Standard complete blood count to predict long-term outcomes in febrile infection-related epilepsy syndrome (FIRES): A multicenter study.Epilepsia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic immune-inflammation index (SII), calculated as platelet count × neutrophil count/lymphocyte count, is a novel biomarker reflecting immune and inflammatory responses. Its prognostic value in patients with subarachnoid hemorrhage (SAH) remains unclear. This meta-analysis aimed to evaluate the association between SII at admission and the short-term functional outcomes of patients with SAH. A systematic search of PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and Wanfang databases identified cohort studies reporting the relationship between SII levels and functional outcomes in SAH. Poor functional outcomes were defined as modified Rankin Scale > 2 or Glasgow Outcome Scale < 4. Heterogeneity was assessed using I² statistic, and data synthesis was performed using a random-effects model by incorporating the influence of heterogeneity. RevMan 5.1 and Stata 17.0 were used for the analyses. Ten cohort studies involving 2,228 patients were included. Meta-analysis revealed that a high SII at admission significantly increased the risk of poor functional outcomes (OR: 3.08, 95% CI: 2.07-4.59, p < 0.001) with moderate heterogeneity (I² = 61%). Subgroup analysis showed a stronger association in studies with SII cutoffs ≥ 1400 compared to < 1400 (p for subgroup difference < 0.001). Meta-regression identified the cutoff value for SII as a significant modifier (p = 0.03) for the association between SII and poor functional outcome. Sensitivity analyses by excluding one dataset at a time showed similar results (p all < 0.05). In conclusion, elevated SII at admission is associated with an increased risk of poor short-term functional outcomes in SAH. These findings highlight SII as a potential prognostic biomarker for early risk stratification in SAH patients.
Indexed as
Identifiers
40016496What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.