ArticleDiabetic medicine : a journal of the British Diabetic Association2025
Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Hypoglycaemia and Cardiac Arrhythmias in Type 1 Diabetes Mellitus: A Mechanistic Review.Journal of personalized medicine · 2026Review
- Clinical and pathophysiological links between hypoglycemia and cardiovascular risk in type 2 diabetes mellitus.Frontiers in clinical diabetes and healthcare · 2026Review
- Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Association between hypoglycemia unawareness and cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus: a prospective cohort study.Diabetology & metabolic syndrome · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aimsHypoglycaemia causes abnormal cardiac repolarisation, which has been related to sympathoadrenal activation. We examined whether individuals with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) were protected against proarrhythmogenic alterations on their electrocardiogram during clinical episodes of hypoglycaemia.
methodsAdults with T1D and IAH underwent 96 h of simultaneous ambulatory electrocardiogram and blinded continuous interstitial glucose (IG) monitoring. Measures of cardiac repolarisation and heart rate variability (HRV) were compared during hypoglycaemia versus time and person-matched euglycaemia. We compared these data to a historical control group of individuals with T1D and no IAH.
resultsFourteen individuals (10/14 female) with a mean (SD) age of 39 (10) years and T1D duration of 24 (9) years were examined. Fourteen daytime and 12 nocturnal hypoglycaemic episodes were analysed. During daytime hypoglycaemia versus euglycaemia, the mean (SD) QT
conclusionsHypoglycaemia can still lead to proarrhythmogenic electrocardiographic changes in individuals with T1D and IAH. We observed diurnal, inter- and intraindividual variability in responses to hypoglycaemia.
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