Evidence map›Paper›PMID 40017148›Full record

ArticleMolecular medicine reports2025

LncPrep + 96kb inhibits ovarian fibrosis by upregulating prolyl oligopeptidase expression.

Hongdan Zhang, Jing Wang, Jianwei Liu, Xiang Fan, Yinuo Jia, Yingtong Huang, Qihui Han, Shimeng Wang, Li Xiao, Xiang Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongdan Zhang *School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Jing Wang *School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Jianwei LiuSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Xiang FanSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Yinuo JiaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Yingtong HuangSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Qihui HanSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Shimeng WangSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Li XiaoSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Xiang LiSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.
Chunping ZhangSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330019, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LncPrep + 96kb is a long non‑coding RNA expressed in murine granulosa cells. The 2.2-kb fragment of lncPrep + 96kb inhibits aromatase expression and estrogen secretion in ovarian granulosa cells. In the present study, lncPrep + 96kb‑knockout (KO) mice were generated, and significant ovarian fibrosis and reduced female fertility through fertility monitoring and superovulation. The augmentation of ovarian fibrosis was observed by Sirius red staining and western blot and

Indexed as

OvaryRNA, Long NoncodingSerine EndopeptidasesAnimalsFemaleFibrosisGranulosa CellsMatrix Metalloproteinase 2MiceMice, KnockoutPPAR gammaProlyl OligopeptidasesTransforming Growth Factor beta1Up-RegulationMatrix Metalloproteinase 2PPAR gammaProlyl OligopeptidasesRNA, Long NoncodingSerine EndopeptidasesTransforming Growth Factor beta1lncPrep + 96kbmatrix metalloproteinase 2ovarian fibrosisperoxisome proliferator activated receptor γprolyl oligopeptidasetransforming growth factor β1

Identifiers

PMID40017148
PMCPMC11894593

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.