Evidence map›Paper›PMID 40017774›Full record

ArticleJACS Au2025

Two-Step Constitutional Isomerization of Saturated Cyclic Amines Using Borane Catalysis.

Charis Amber, Timothée M Petitjean, Giedre Sirvinskaite, Ryan T Steele, Breanna Sprague, Julius Domack, David W Small, Richmond Sarpong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Skeletal Editing Strategies Driven by Total Synthesis.Accounts of chemical research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charis AmberDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0002-3671-5388
Timothée M PetitjeanDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Giedre SirvinskaiteDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Ryan T SteeleDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0009-0007-7150-8249
Breanna SpragueDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Julius DomackDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
David W SmallDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0002-3316-1885
Richmond SarpongDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0002-0028-6323

Funding

Strategies and Methods for Complex Molecule Synthesis: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer ConsoleR35GM130345 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Richmond Sarpong · 2019 to 2026
$5.4M
High Performance Computing Cluster for Public Health Driven Molecular Science - Core FacilityS10OD023532 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DURKIN, KATHLEEN A · 2017 to 2017
$434k
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NIGMS NIH HHS R35 GM130345NIH HHS S10 OD023532NIH HHS S10 OD024998
6 · The paper itself

Abstract

The prevalence of saturated azacycles within pharmaceuticals, natural products, and agrochemicals has prompted the development of many methods that modify their periphery. In contrast, technologies that interconvert distinct saturated azacyclic frameworks, which would uniquely facilitate access to underexplored chemical space, are highly limited. Existing approaches for modifying the core of azacycles usually require either the installation of reactive functionality, which must later be removed in subsequent steps, or the use of tailored substrates, limiting applicability to drug discovery. Herein, we report a borane-catalyzed contraction of saturated

Identifiers

PMID40017774
PMCPMC11862921

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.