Evidence map›Paper›PMID 40017822›Full record

ArticleFrontiers in neuroimaging2025

Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [

Maiko Ono, Rena Kono, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maiko OnoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Rena KonoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Kosei HirataDepartment of Neuroscience, Genetics, and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Keita SaitoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Motonao NakaoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Yoichi TakakusagiInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Rikita ArakiBiospin Division, Application Department, Bruker Japan K.K., Yokohama, Japan.
Akira SumiyoshiInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Yuhei TakadoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer's disease. Hyperpolarized [1-

Indexed as

agingawake conditionbicarbonatecarbon-13 MRSchemical shift imaginghyperpolarized [1-13C]pyruvatemouse brain

Identifiers

PMID40017822
PMCPMC11861090

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.