Evidence map›Paper›PMID 40018732›Full record

ArticleFrontiers in radiology2025

Following changes in brain structure and function with multimodal MRI in a year-long prospective study on the development of Type 2 diabetes.

Yingjie Wang, Richard Ortiz, Arnold Chang, Taufiq Nasseef, Natalia Rubalcaba, Chandler Munson, Ashley Ghaw, Shreyas Balaji, Yeani Kwon, Deepti Athreya and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yingjie WangCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Richard OrtizDepartment of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM, United States.
Arnold ChangCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Taufiq NasseefDepartment of Mathematics, College of Science and Humanity Studies, Prince Sattam Bin Abdulaziz University, Riyadh, Saudi.
Natalia RubalcabaCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Chandler MunsonCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Ashley GhawCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Shreyas BalajiCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Yeani KwonCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Deepti AthreyaCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Shruti KedharnathCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Praveen P KulkarniCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.
Craig F FerrisCenter for Translational NeuroImaging, Northeastern University, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To follow disease progression in a rat model of Type 2 diabetes using multimodal MRI to assess changes in brain structure and function. Material and methods: Female rats ( Results: Diet fed rats presented with elevated plasma glucose levels as early as 3 months and a significant gain in weight by 6 months as compared to controls. There were no significant changes in cognitive or motor behavior over the yearlong study but there was a significant increase in sensitivity to peripheral pain in diet fed rats. There were region specific decreases in brain volume e.g., basal ganglia, thalamus and brainstem in diet fed rats. These same regions showed elevated measures of water diffusivity evidence of putative vasogenic edema. By 6 months, widespread hyperconnectivity was observed across multiple brain regions. By 12 months, only the cerebellum and hippocampus showed increased connectivity, while the hypothalamus showed decreased connectivity in diet fed rats. Conclusions: Noninvasive multimodal MRI identified site specific changes in brain structure and function in a yearlong longitudinal study of Type 2 diabetes in rats. The identified diabetic-induced neuropathological sites may serve as biomarkers for evaluating the efficacy of novel therapeutics.

Indexed as

cerebellumdiffusion weighted imagingglucose toleranceresting state functional connectivityvoxel based morphometry

Identifiers

PMID40018732
PMCPMC11865244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.