Evidence map›Paper›PMID 40020673›Full record

ArticleImmunity2025

The endogenous antigen-specific CD8

Leena Abdullah, Francesco E Emiliani, Chinmay M Vaidya, Hannah Stuart, Shawn C Musial, Fred W Kolling, Joshua J Obar, Pamela C Rosato, Margaret E Ackerman, Li Song and 2 more

Abstract read
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Atomistic TCR-ligand interactions instruct memory T-cell differentiation.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Leena AbdullahDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Francesco E EmilianiDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Chinmay M VaidyaDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Hannah StuartDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Shawn C MusialDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Fred W KollingDartmouth Cancer Center, Lebanon, NH 03756, USA.
Joshua J ObarDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Pamela C RosatoDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Dartmouth Cancer Center, Lebanon, NH 03756, USA.
Margaret E AckermanThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA; Dartmouth Cancer Center, Lebanon, NH 03756, USA.
Li SongDepartment of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Dartmouth Cancer Center, Lebanon, NH 03756, USA.
Aaron McKennaDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Dartmouth Cancer Center, Lebanon, NH 03756, USA.
Yina H HuangDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Dartmouth Cancer Center, Lebanon, NH 03756, USA; Department of Pathology and Laboratory Medicine, Dartmouth Health, Lebanon, NH 03756, USA. Electronic address: yina@dartmouth.edu.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI Lauren J Walker · 2019 to 2026
$27.2M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
PIP3-INDEPENDENT REGULATION OF AKT1 ACTIVITY IN T CELLSR01AI089805 · NIAID · WASHINGTON UNIVERSITY · PI HUANG, YINA HSING · 2011 to 2021
$4.2M
Sustaining Tissue Resident Memory T cellsR01CA254042 · NCI · DARTMOUTH COLLEGE · PI Yina Hsing Huang, Mary Jo Turk · 2022 to 2026
$2.6M
Directing Antibody Effector Activity via Controlled IgG Subclass SwitchingR01AI131975 · NIAID · DARTMOUTH COLLEGE · PI ACKERMAN, MARGARET E · 2017 to 2020
$2.6M
Annotated lineage trees of murine developmentDP2GM149750 · NIGMS · DARTMOUTH COLLEGE · PI MCKENNA, AARON H · 2022 to 2025
$2.5M
Acquisition of the NextSeq2000 Sequencing platform to Increase Next Generation Sequencing Throughput While Reducing Costs at DartmouthS10OD030242 · OD · DARTMOUTH COLLEGE · PI KOLLING IV, FRED W · 2021 to 2021
$321k
10X Genomics Chromium Single-cell Sequencing to Expand Research At DartmouthS10OD025235 · OD · DARTMOUTH COLLEGE · PI TOMLINSON, CRAIG R · 2018 to 2018
$125k
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA254042NIAID NIH HHS R01 AI089805NIAID NIH HHS R01 AI131975NIAID NIH HHS T32 AI007363NIGMS NIH HHS DP2 GM149750NIGMS NIH HHS P20 GM130454NIH HHS S10 OD025235NIH HHS S10 OD030242
6 · The paper itself

Abstract

Generating balanced populations of CD8

Indexed as

CD8-Positive T-LymphocytesMemory T CellsReceptors, Antigen, T-CellAnimalsAntigensCell DifferentiationClone CellsImmunologic MemoryMiceMice, Inbred C57BLMice, TransgenicPhylogenyAntigensReceptors, Antigen, T-Cellendogenous CD8(+) T cell responsehierarchal lineage tracingT cell fate bias

Identifiers

PMID40020673
PMCPMC11903169

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.