Evidence map›Paper›PMID 40021219›Full record

ArticleLife science alliance2025

Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2b

Konner R Kirwan, Veria Puerta-Alvarado, Clarissa L Waites

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Konner R KirwanNeurobiology and Behavior PhD Program, Columbia University, New York, NY, USA.
Veria Puerta-AlvaradoNeurobiology and Behavior PhD Program, Columbia University, New York, NY, USA.ORCID 0000-0002-2057-6838
Clarissa L WaitesDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA cw2622@cumc.columbia.edu.ORCID 0000-0003-4263-5576

Funding

Uncovering stress-induced mechanisms of Tau pathology in Alzheimer's diseaseRF1AG069941 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Clarissa Leigh Waites · 2020 to 2026
$5.5M
Uncovering the Roles of Ubiquitination and the ESCRT Pathway in Degradative Sorting of SV Proteins.R01NS080967 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAITES, CLARISSA LEIGH · 2013 to 2023
$3.8M
Uncovering stress-induced mechanisms of Tau pathology in Alzheimer's diseaseR01AG069941 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAITES, CLARISSA LEIGH · 2024 to 2024
$552k
NIA NIH HHS R01 AG069941NIA NIH HHS RF1 AG069941NINDS NIH HHS R01 NS080967
6 · The paper itself

Abstract

CHMP2b is a core component of the ESCRT pathway that catalyzes formation of multivesicular bodies for endolysosomal protein degradation. Although mutation/loss-of-function of CHMP2b promotes presynaptic dysfunction and degeneration, indicating its critical role in presynaptic protein homeostasis, the mechanisms responsible for CHMP2b localization and recruitment to synapses remain unclear. Here, we characterize CHMP2b axonal trafficking and show that its transport and recruitment to presynaptic boutons, as well as its cotransport with other ESCRT proteins, are regulated by neuronal activity. In contrast, the frontotemporal dementia-causative CHMP2b

Indexed as

Axonal TransportEndosomal Sorting Complexes Required for TransportAnimalsAxonsFrontotemporal DementiaHumansKinesinsMiceMutationNeuronsPresynaptic TerminalsProtein BindingProtein TransportCHMP2B protein, humanEndosomal Sorting Complexes Required for TransportKinesins

Identifiers

PMID40021219
PMCPMC11871287

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.