ArticleScientific reports2025
Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Peripheral CD4 T-Cell State Remodeling in Migraine Revealed by Single-Cell RNA Sequencing.Journal of molecular neuroscience : MN · 2026Article
- The emerging role of epigenetic regulation in pain sensitization associated with headache disorders.The journal of headache and pain · 2025Review
- Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology.The journal of headache and pain · 2025Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinase 14 (MAPK14) has a fundamental role in the development of different inflammatory and neurodegenerative disorders. However, its roles in the pathoetiology of migraine are not clear. The current case-control study focused on expression analysis of MAPK14 and related long non-coding RNAs (lncRNAs) in the circulation of migraineurs compared with healthy controls. Data showed remarkable elevation of expression levels of MAPK14, HLA Complex Group 11 (HCG11), zinc ribbon domain-containing 1-antisense 1 (ZNRD1-AS1), RAD51 antisense RNA 1 (RAD51-AS1) and long noncoding RNA-activated by DNA damage (NORAD) in both groups of migraineurs (with aura and without aura) compared with controls. The accuracy of expression levels of MAPK14, HCG11, ZNRD1-AS1, RAD51-AS1 and NORAD for differentiating migraineurs from controls was 85.71%, 81.56%, 85.11%, 77.8% and 94.33%, respectively. Thus, MAPK14 and its related lncRNAs are putative markers for migraine and might participate in the pathogenesis of this neurologic condition.
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