ArticleBrain and behavior2025
A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Internal carotid artery bifurcation aneurysms are probably formed to decrease the abnormally-enhanced hemodynamic stresses caused by direct flow impaction.Quantitative imaging in medicine and surgery · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntracranial aneurysms (IAs) are relatively common cerebrovascular anomalies. Melatonin could modulate inflammatory and offers neuroprotective effects, and its role in IA has not been fully elucidated.
methodsAn elastase-induced IA mouse model was constructed and melatonin (150 mg/kg) was administered to investigate its therapeutic effects on IA. Aneurysm formation was observed by bromophenol blue gelatin perfusion, and the pathology changes in IA mice were examined using hematoxylin-eosin (HE) staining. The potential mechanisms of melatonin treatment of IA were explored using western blot, enzyme-linked immunosorbent, real-time qPCR, immunohistochemistry, and flow cytometry. An H
resultsThe formation of aneurysms was observed in the circle of Willis in the IA mice. Melatonin treatment alleviated the thinning of blood vessel walls and disruption of the internal elastic lamina in IA mice. The levels of Bcl-2 were significantly increased and Bax and cleaved caspase-3 were decreased in IA mice with melatonin treatment, suggesting reduced apoptosis. Furthermore, melatonin reduced levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) in IA mice. The H
conclusionMelatonin mitigates IA injury by modulating immune cells and hypoxia-related factors. These findings provide an exploratory foundation for therapeutic strategies in IA.
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