Evidence map›Paper›PMID 40022286›Full record

ArticleBrain and behavior2025

Cognitive Function Deficits Associated With Type 2 Diabetes and Retinopathy: Volumetric Brain MR Imaging Study.

Ece Ozdemir Oktem, Dila Sayman, Sevilay Ayyildiz, Çaglar Oktem, Lutfiye Ipek, Behcet Ayyildiz, Fatih Aslan, Emin Utku Altindal, Nilay Yagci, Rumeysa Dikici and 5 more

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Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Ece Ozdemir OktemDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Dila SaymanDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Sevilay AyyildizSchool of Medicine, TUM-NIC Neuroimaging Center, Technical University of Munich, Munich, Germany.
Çaglar OktemDepartment of Ophthalmology, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Lutfiye IpekDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Behcet AyyildizDepartment of Anatomy, Kocaeli University, Kocaeli, Turkey.
Fatih AslanDepartment of Ophthalmology, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Emin Utku AltindalDepartment of Ophthalmology, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Nilay YagciDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Rumeysa DikiciDepartment of anatomy, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Ramazan KaracaDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Şeyda CankayaDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Seda AvniogluDepartment of anatomy, Alanya Alaaddin Keykubat University, Antalya, Turkey.
Halil Aziz VeliogluCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York, USA.
Burak YulugDepartment of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, Antalya, Turkey.ORCID https://orcid.org/0000-0002-9704-6173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType 2 diabetes mellitus is a ubiquitous chronic inflammatory disease with deleterious effects on various tissues, including the kidney, retina, and peripheral nerves. Studies using histopathology and magnetic resonance imaging have revealed that diabetes-related chronic hyperglycemia may impact the brain's essential functioning by causing microvascular damage. The aim of this study was to examine the cognitive functioning of type 2 diabetic individuals with and without retinopathy by evaluating their morphological, structural, and biochemical differences.

methodsDemographic characteristics, education level, type of diabetes mellitus (DM), disease duration, treatment received, other diabetic complications, such as nephropathy and neuropathy, and detailed medical histories were recorded. All participants underwent an extensive neuropsychological examination with Montreal Cognitive Assessment (MoCA) testing. Brain magnetic resonance imaging was performed to evaluate gray matter volume differences between the groups.

resultsGray matter volume differences between the groups were observed. Differences were observed after multiple corrections (age, education, and total intracranial volume [TIV]). First, the diabetic retinopathy group exhibited a significantly smaller gray matter volume in the right inferior temporal gyrus than the diabetic group (p = 0.032). In addition, the diabetic retinopathy group exhibited a significantly smaller gray matter volume than the control group in the right insula (lateral and central part) (p = 0.011). In addition, MoCA scores exhibited significant correlation with the two regions emerging as statistically significant in our analyses (the right inferior temporal gyrus and right insula) (p = 0.003, p = 0.002, respectively).

conclusionOur results suggest the presence of a neurodegenerative process associated with cognitive dysfunction that is particularly prominent in the retinopathy stage of DM.

Indexed as

BrainCognitive DysfunctionDiabetes Mellitus, Type 2Diabetic RetinopathyAgedFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsMRIretinopathytype 2 diabetes

Identifiers

PMID40022286
PMCPMC11870829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.