Evidence map›Paper›PMID 40025468›Full record

ArticleBMC microbiology2025

The high efficiency protective effectiveness of a newly isolated myoviruses bacteriophage vB_AceP_PAc in protecting mice from Aeromonas caviae infection in mice.

Chao Feng, Lu Wang, Huifang Bai, Qixing Huang, Shuang Liang, Ruiqi Liang, Jiahao Yu, Shun Wang, Hui Guo, Sayed Haidar Abbas Raza and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pathogens (Basel, Switzerland) · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chao Feng *College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Lu Wang *Institute of Intelligent Oncology, Chongqing University, Chongqing, 400030, China.
Huifang BaiCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Qixing HuangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Shuang LiangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Ruiqi LiangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Jiahao YuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Shun WangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Hui GuoCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Sayed Haidar Abbas RazaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Xiaofeng ShanCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Dongxing ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Wuwen SunCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. sunwuwen@borui.com.
Lei ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. zhanglei0221@jlau.edu.cn.

Funding

Jilin Province Science and technology development plan project 20220202067N C
6 · The paper itself

Abstract

Phage therapy is an effective strategy to combat multidrug resistance in bacteria and has been increasingly utilized to protect animals from bacterial infections. This study involved the isolation and purification of a novel myoviruses phage, vB_AceP_PAc, from a drug-resistant bacterial strain Aeromonas caviae. Genome sequence analysis based on nucleotide sequences revealed that vB_AceP_PAc shared significant similarity with the genomes of 10 other Aeromonas phages, with the highest coverage rate of 52% with phiA047. Intraperitoneal injection of 1 × 10⁷ CFU/mL (100 µL/mouse) A. caviae AC-CY resulted in diarrhea in mice three days later. At this time, oral administration of 1 × 10

Indexed as

Aeromonas caviaeBacteriophagesGram-Negative Bacterial InfectionsMyoviridaePhage TherapyAnimalsDiarrheaDisease Models, AnimalFemaleGenome, ViralMiceBacteriophageDiarrhoeaGenome analysisGut microbiotaIntestinal barrier function

Identifiers

PMID40025468
PMCPMC11874395

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.