Evidence map›Paper›PMID 40026237›Full record

ArticleFEBS letters2025

The intracellular domain of TLR2 is capable of high-affinity Zn binding: possible outcomes for the receptor activation.

Vladislav A Lushpa, Cong Lin, Irina A Talyzina, Marina V Goncharuk, Eduard V Bocharov, Alexander S Arseniev, Xiaohui Wang, Sergey A Goncharuk, Konstantin S Mineev

Abstract read
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In one paragraph

Article in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vladislav A LushpaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.ORCID https://orcid.org/0000-0002-1788-1153
Cong LinLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Irina A TalyzinaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
Marina V GoncharukShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.ORCID https://orcid.org/0000-0002-6984-7125
Eduard V BocharovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
Alexander S ArsenievShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
Xiaohui WangLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Sergey A GoncharukShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.ORCID https://orcid.org/0000-0002-0263-6462
Konstantin S MineevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.ORCID https://orcid.org/0000-0002-2418-9421

Funding

Deutsche Forschungsgemeinschaft CRC1507Russian Science Foundation 22-14-00020
6 · The paper itself

Abstract

Toll-like receptors (TLRs) are important players in the innate immune system. Binding of pathogen-related molecules to the extracellular domains of TLRs initiates signalosome assembly, a key event in signal transduction. Despite extensive research on individual receptor domains, the mechanism of signalosome assembly remains unclear. Recent evidence suggests that the intracellular TIR domain of TLR1 binds zinc ions, with cysteines playing a pivotal role in binding and receptor activation. This study explores the zinc-binding ability of the TLR2 TIR domain (TLR2

Indexed as

NMRoligomerization, activationTIR domainTLR2, zincToll‐like receptorzinc binding

Identifiers

PMID40026237
PMCPMC12258416

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.