Evidence map›Paper›PMID 40027245›Full record

ArticleData in brief2025

Sprouting and network data assessed in the chicken aortic ring assay under stimulation with human adipose-derived stem cell secretomes harvested from single cells or spheroids of different sizes.

Petra Wolint, Silvan Hofmann, Julia von Atzigen, Roland Böni, Iris Miescher, Pietro Giovanoli, Maurizio Calcagni, Maximilian Y Emmert, Johanna Buschmann

Abstract read
In one paragraph

Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Petra WolintDivision of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland.
Silvan HofmannDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Julia von AtzigenDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Roland BöniWhite House Center for Liposuction, 8044 Zurich, Switzerland.
Iris MiescherDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Pietro GiovanoliDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Maurizio CalcagniDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Maximilian Y EmmertInstitute for Regenerative Medicine (IREM), University of Zurich, 8952 Zurich, Switzerland.
Johanna BuschmannDivision of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aortic ring assay is widely used to assess the angiogenic modulation evoked by various drugs. However, different parameters are used as readouts and there is no congruence in terminology. In addition, some researchers use one set of parameters, and other researchers choose parameters that overlap to some extent, but miss a part of these parameters, rendering a direct comparison of the readouts and results difficult [1]. Therefore, we present data acquired in the chicken aortic ring assay that cover the full spectrum of possible readouts - exemplified by stimulation with secretomes harvested from human adipose-derived stem cells, cultivated either as single cell monolayer culture or as 3D spheroids, sized 250 cells/spheroid or 8000 cells/spheroid, respectively.

Indexed as

AngiogenesisAortic ring assayChickenMesenchymal stem cellsSecretomeSpheroid

Identifiers

PMID40027245
PMCPMC11870177

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.