Evidence map›Paper›PMID 40027730›Full record

ArticlebioRxiv : the preprint server for biology2025

Lack of motor defects and ALS-like neuropathology in heterozygous

Devesh C Pant, Museer A Lone, Janani Parameswaran, Fuying Ma, Prisha Dutta, Zitong Wang, Jaekeun Park, Sumit Verma, Thorsten Hornemann, Jie Jiang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Devesh C PantDepartment of Cell Biology, Emory University, Atlanta, GA, USA.
Museer A LoneInstitute for Clinical Chemistry, University of Zurich, Zurich, Switzerland.
Janani ParameswaranDepartment of Cell Biology, Emory University, Atlanta, GA, USA.
Fuying MaDepartment of Cell Biology, Emory University, Atlanta, GA, USA.
Prisha DuttaDepartment of Cell Biology, Emory University, Atlanta, GA, USA.
Zitong WangDepartment of Cell Biology, Emory University, Atlanta, GA, USA.
Jaekeun ParkCenter for Systems Imaging Core, Emory University, Atlanta, GA, USA.
Sumit VermaDepartment of Pediatrics and Neurology, Emory University, Atlanta, GA, USA.
Thorsten HornemannInstitute for Clinical Chemistry, University of Zurich, Zurich, Switzerland.
Jie JiangDepartment of Cell Biology, Emory University, Atlanta, GA, USA.

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Cell-type-specific toxicity of C9orf72 repeat expansions in FTD and ALSR01AG068247 · NIA · EMORY UNIVERSITY · PI JIANG, JIE · 2020 to 2024
$2.0M
NCATS NIH HHS UL1 TR000454NIA NIH HHS R01 AG068247
6 · The paper itself

Abstract

Mutations in the human

Indexed as

motor neuron diseasesphingolipidsSPTLC1

Identifiers

PMID40027730
PMCPMC11870480

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.