Evidence map›Paper›PMID 40028342›Full record

ArticleFrontiers in immunology2025

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation.

Yumeng Sun, Subha Sen, Rajesh Parmar, Janice Arakawa-Hoyt, Monica Cappelletti, Maura Rossetti, David W Gjertson, Tara K Sigdel, Minnie M Sarwal, Joanna M Schaenman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. The role of CD8Frontiers in immunology · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yumeng SunDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Subha SenDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Rajesh ParmarDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Janice Arakawa-HoytDepartment of Microbiology and Immunology, Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.
Monica CappellettiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Maura RossettiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
David W GjertsonDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Tara K SigdelDepartment of Surgery, Division of Multi Organ Transplantation, University of California, San Francisco, San Francisco, CA, United States.
Minnie M SarwalDepartment of Surgery, Division of Multi Organ Transplantation, University of California, San Francisco, San Francisco, CA, United States.
Joanna M SchaenmanDivision of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Suphamai BunnapradistDivision of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Lewis L LanierDepartment of Microbiology and Immunology, Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, United States.
Harry Pickering *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Elaine F Reed *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, SARWAL, MINNIE M · 2017 to 2021
$11.2M
NIAID NIH HHS U19 AI128913
6 · The paper itself

Abstract

Introduction: Cytomegalovirus (CMV) viremia remains a major contributor to clinical complications in solid organ transplant (SOT) patients, including organ injury, morbidity and mortality. Given their critical role in antiviral defense, CD8+ T cells are essential for protective immunity against CMV. Methods: Using single-cell RNA sequencing, we investigated the transcriptional signatures and developmental lineages of CD8+ T cells in eight immunosuppressed kidney transplant recipients (KTRs) who received organs from CMV-seropositive donors. Results were validated in a cohort of 62 KTRs using immunophenotyping. Results: Our data revealed a significant influence of CMV serostatus on transcriptional variance of CD8+ memory T cells, associating with the first principal component from a global analysis of CD8+ T cells (p =0.0406), forming a continuum with five principal differentiation trajectories driven by CMV primary infection or reactivation. Following CMV primary infection, CD8+ T cells were hallmarked by restrained effector-memory differentiation. CD8+ T cells during CMV reactivation diverged non-linearly into senescent-like cells with signatures of arrested cell cycle, diminished translational activity and downregulated Discussion: These results provide insights into the transcriptional regulation that influences the generation of CD8+ T cell immunity to CMV and may inform strategics for monitoring host immune response to CMV to better identify and introduce therapeutic intervention to patients at risk of developing clinically significant CMV viremia.

Indexed as

CD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsKidney TransplantationLectins, C-TypeReceptors, ImmunologicReceptors, Interleukin-7Virus ActivationAdultAgedFemaleHumansImmunologic MemoryInterleukin-7 Receptor alpha SubunitMaleMiddle AgedIL7R protein, humanInterleukin-7 Receptor alpha SubunitKLRG1 protein, humanLectins, C-TypeReceptors, ImmunologicReceptors, Interleukin-7CD8+ T cellscytomegalovirus (CMV)effector T cell differentiationkidney transplantationsingle-cell RNA sequencing (sc-RNA seq)

Identifiers

PMID40028342
PMCPMC11868092

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.