Evidence map›Paper›PMID 40028843›Full record

ArticleJournal of the American Heart Association2025

Modeling

Tarsha Ward, Sarah U Morton, Gabriela Venturini, Warren Tai, Min Young Jang, Joshua Gorham, Dan Delaughter, Lauren K Wasson, Zahra Khazal, Jason Homsy and 8 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tarsha WardDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0003-3740-3797
Sarah U MortonDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0002-7816-2646
Gabriela VenturiniDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0003-2913-2296
Warren TaiDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0001-9355-7198
Min Young JangDepartment of Genetics Harvard Medical School Boston MA USA.
Joshua GorhamDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0001-5969-4690
Dan DelaughterDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0002-5352-2502
Lauren K WassonDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0002-5193-5215
Zahra KhazalDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0009-0003-7000-105X
Jason HomsyDepartment of Genetics Harvard Medical School Boston MA USA.
Bruce D GelbMindich Child Health and Development Institute and the Department of Pediatrics and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA.ORCID 0000-0001-8527-5027
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital Harvard Medical School Boston MA USA.ORCID 0000-0003-3438-5685
Benoit G BruneauGladstone Institutes San Francisco CA USA.
Martina BruecknerDepartment of Genetics and Pediatrics Yale University School of Medicine New Haven CT USA.
Martin Tristani-FirouziDivision of Pediatric Cardiology University of Utah and School of Medicine Salt Lake City UT USA.ORCID 0000-0001-5916-442X
Steven R DePalmaDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0002-0381-5016
Christine SeidmanDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0001-6380-1209
J G SeidmanDepartment of Genetics Harvard Medical School Boston MA USA.ORCID 0000-0002-9082-3566

Funding

MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
The Epigenetic Landscape of Heart DevelopmentUM1HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, POLLARD, KATHERINE S. · 2015 to 2019
$4.7M
Regulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4M
Molecular Causes of Down Syndrome Associated Congenital Heart Disease and Other PhenotypesR01HL151257 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2019 to 2019
$3.7M
Identifying unrecognized genetic causes of congenital heart diseaseR01HL162356 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI William Tswenching Pu, CHRISTINE E SEIDMAN · 2024 to 2026
$2.3M
Genetics of conotruncal defects and associated neurodevelopmental outcomesUM1HL098123 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELB, BRUCE D · 2015 to 2019
$2.3M
Genetics and genomics of congenital heart disease and associated neurodevelopmental abnormalitiesUM1HL098162 · NHLBI · YALE UNIVERSITY · PI BRUECKNER, MARTINA, GUPTA, ABHA RANI · 2015 to 2019
$2.2M
NHLBI NIH HHS R01 HL151257NHLBI NIH HHS R01 HL162356NHLBI NIH HHS T32 HL007208NHLBI NIH HHS UM1 HL098123NHLBI NIH HHS UM1 HL098162NHLBI NIH HHS UM1 HL098166NHLBI NIH HHS UM1 HL098179
6 · The paper itself

Abstract

backgroundSMAD2 is a coregulator that binds a variety of transcription factors in human development. Heterozygous METHODS AND

resultsRare

conclusions

Indexed as

Heart Defects, CongenitalInduced Pluripotent Stem CellsMutation, MissenseMyocytes, CardiacSmad2 ProteinCell DifferentiationEpigenesis, GeneticExome SequencingFemaleGenetic Predisposition to DiseaseHaploinsufficiencyHumansLoss of Function MutationMalePhenotypeSmad2 ProteinSMAD2 protein, humancongenital heart diseaseCRISPR/Cas9 gene editinginduced pluripotent stem cellsmechanisms of transcriptional regulationSMAD2

Identifiers

PMID40028843
PMCPMC12184555

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.