SynthesisJournal of the American Heart Association2025
Exercise Intolerance in Type 2 Diabetes: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The impact of type 2 diabetes on tendon material properties and locomotor function in the db/db mouse.Experimental physiology · 2026Article
- Correlation between cardiorespiratory fitness and body composition in individuals with different glucose metabolism statuses.Frontiers in endocrinology · 2026Article
- Latest advances and controversies of exercise therapy in the management of type 2 diabetes.Frontiers in endocrinology · 2026Review
- TAS1R3 Regulates GTPase Signaling in Human Skeletal Muscle Cells for Glucose Uptake.International journal of molecular sciences · 2025Article
- Assessing the Impact of BMI and Glycaemic Control on Cardiac Autonomic Neuropathy in Patients with Early and Long-standing Diabetes Mellitus: A Window of Opportunity.Annals of neurosciences · 2025Review
- Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice.Journal of sport and health science · 2025Article
- Effects of Lower Limb-Focused Low-Intensity Resistance Exercise Using Slow Movements on Locomotive Syndrome in Patients with Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2025Article
- Telehealth for Integrated Cardiovascular and Diabetes Management: A Scoping Review.Journal of diabetes research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTo analyze the effect of type 2 diabetes (T2D) on cardiorespiratory fitness.
methodsA multilevel model using restricted maximum likelihood method was used to analyze pooled data. Inclusion criteria included adults aged >18 years, one group of individuals needed to have been diagnosed with T2D, the control group must not have had insulin resistance, the study must report peak oxygen uptake, there was no exercise training before tests of functional capacity, and subjects may not have had overt cardiovascular disease, cancer, transplant surgery, or bariatric surgery. Moderators assessed were sample demographics (age, body mass index, sex, and time since T2D diagnosis) and cardiovascular outcomes (eg, echocardiographic variables, blood pressure).
resultsAbsolute (cohorts n=30; subjects n=1152; mean difference, -0.29 L/min [95% CI, -0.37 to -0.22 L/min];
conclusionsMarkers of cardiac diastolic function (early mitral inflow velocity/early mitral annulus velocity and left atrial volume index) and time since diabetes diagnosis may contribute to exercise intolerance in T2D, although there is a lack of data in young/older adults and newly diagnosed individuals. As cardiorespiratory fitness predicts both all-cause mortality and cardiovascular morbidity and mortality, these data have important implications for risk reduction in individuals with T2D.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.