Evidence map›Paper›PMID 40028859›Full record

ArticleAnnals of medicine2025

Excessive bile acids level predisposes to adverse perinatal outcomes in women with abnormal pre-pregnancy body mass index.

Yulai Zhou, Juan Li, Jinwen Zhang, Huan Li, Fuzhen Song, Wei Gu, Weibin Wu

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yulai ZhouDepartment of Obstetrics, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Juan LiDepartment of Pathology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jinwen ZhangShanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Huan LiDepartment of Obstetrics and Gynecology, Songjiang Maternity and Child Health Hospital, Shanghai, China.
Fuzhen SongDepartment of Radiology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wei GuDepartment of Obstetrics, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Weibin WuShanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.ORCID 0000-0003-3637-754X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth low/high pre-pregnancy body mass index (BMI) and increased bile acid levels during pregnancy (known as gestational hypercholanemia) were risk factors for adverse pregnancy outcomes, with limited information on their joint effects.

methodsA total of 63,066 pregnant women were involved in a large retrospective cohort study from May 2014 to December 2018 in Shanghai, China. Data of pregnancy outcomes including hypercholanemia, hypertensive disorders in pregnancy (HDP), preterm delivery, and small for gestation age (SGA), were obtained for multivariable logistic analysis.

resultsPre-pregnancy BMI was negatively associated with serum total bile acid (TBA) concentrations during gestation and the risk of hypercholanemia (

conclusionsLow maternal BMI before pregnancy was an independent risk factor for hypercholanemia. Additionally, pre-pregnancy underweight or OWO may amplify the effect of hypercholanemia on adverse pregnancy outcomes. Thus, pre-pregnancy BMI should be considered in the management of adverse perinatal outcomes related to gestational hypercholanemia.

Indexed as

Bile Acids and SaltsPregnancy ComplicationsAdultBody Mass IndexChinaFemaleGestational Weight GainHumansHypertension, Pregnancy-InducedInfant, NewbornInfant, Small for Gestational AgeObesityOverweightPregnancyPregnancy OutcomePremature BirthBile Acids and Saltsadverse pregnancy outcomesgestational hypercholanemiajoint effectPre-pregnancy BMItotal bile acid

Identifiers

PMID40028859
PMCPMC11878157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.