Evidence map›Paper›PMID 40029440›Full record

ArticleMolecular biology reports2025

The G allele of the rs4344 polymorphism of the angiotensin-converting enzyme gene is associated with alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in Brazilian hypertensive patients.

Lívia da C Agostini, Renata B M E Silva, Nayara N T Silva, Ana Cláudia F Lopes, Vanessa de A Belo, Wendel Coura-Vital, Luiz Fernando de M Teixeira, Angélica A Lima, Glenda Nicioli da Silva

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lívia da C Agostini *Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Renata B M E Silva *Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Nayara N T SilvaDepartamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Ana Cláudia F LopesDepartamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Vanessa de A BeloPrograma de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Wendel Coura-VitalPrograma de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Luiz Fernando de M TeixeiraDepartamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Angélica A LimaPrograma de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Glenda Nicioli da SilvaPrograma de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil. nicioli@ufop.edu.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305277/2023-5, CNPq Research Productivity GrantCoordination for the Improvement of Higher Education Personnel 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Brasil APQ-03555-22Municipal Health Department of Ouro Preto 18.295.295/0001-36Pró-Reitoria de Pesquisa e Pós-Graduação, Universidade Federal de Ouro Preto 23109.016819/2023-81 and 23109.009436/2023-56
6 · The paper itself

Abstract

backgroundThe association of genetic variants and environmental factors contribute to increased susceptibility to arterial hypertension (AH). Polymorphisms of the angiotensin-converting enzyme (ACE) gene have been identified as a genetic risk factor related to blood pressure (BP) levels and liver function, since they influence the renin-angiotensin-aldosterone system (RAAS).

objectiveTo evaluate the influence of the rs4344 polymorphism of the ACE gene on AH and biochemical parameters of liver function (ALT, AST, GGT and ALP) in normotensive and hypertensive patients. METHOD AND

resultsThe identification of the polymorphism was performed by qPCR, using the TaqMan

conclusionsOur findings indicated that the rs4344 variant of the ACE gene is linked to impaired liver function in hypertensive individuals.

Indexed as

Alanine Transaminasegamma-GlutamyltransferaseHypertensionPeptidyl-Dipeptidase AAdultAgedAllelesBlood PressureBrazilFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedACE protein, humanAlanine Transaminasegamma-GlutamyltransferasePeptidyl-Dipeptidase AACE geneHypertensionLiver function

Identifiers

PMID40029440

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.