Evidence map›Paper›PMID 40029778›Full record

ReviewAnimal models and experimental medicine2025

Progress in research on osteoporosis secondary to SARS-CoV-2 infection.

Jinlong Wang, Yibai Xiong, Zhiqi Song, Yanhong Li, Ling Zhang, Chuan Qin

Abstract readReview
In one paragraph

Review in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinlong WangInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC, Beijing, China.ORCID 0009-0003-3284-3643
Yibai XiongInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC, Beijing, China.
Zhiqi SongInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC, Beijing, China.
Yanhong LiInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC, Beijing, China.
Ling ZhangInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC, Beijing, China.ORCID 0000-0002-1316-515X
Chuan QinInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC, Beijing, China.ORCID 0000-0002-6261-1232

Funding

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-034,2023-I2M-2-001Key-Area Research and Development Program of Guangdong Province 2022B1111020005State Key Laboratory Special Fund 2060204The Foundation for Innovative Research Groups of the National Natural Science Foundation of China 82221004
6 · The paper itself

Abstract

The World Health Organization has declared that COVID-19 no longer constitutes a "public health emergency of international concern," yet the long-term impact of SARS-CoV-2 infection on bone health continues to pose new challenges for global public health. In recent years, numerous animal model and clinical studies have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to secondary osteoporosis. The mechanisms involved are related to the virus's direct effects on bone tissue, dysregulation of the body's inflammatory response, hypoxia, noncoding RNA imbalance, and metabolic abnormalities. Although these studies have unveiled the connection between SARS-CoV-2 infection and osteoporosis, current research is not comprehensive and in depth. Future studies are needed to evaluate the long-term effects of SARS-CoV-2 on bone density and metabolism, elucidate the specific mechanisms of pathogenesis, and explore potential interventions. This review aims to collate existing research literature on SARS-CoV-2 infection-induced secondary osteoporosis, summarize the underlying mechanisms, and provide direction for future research.

Indexed as

COVID-19OsteoporosisSARS-CoV-2AnimalsBone DensityHumansbone metabolismCOVID‐19long COVIDosteoporosisSARS‐CoV‐2

Identifiers

PMID40029778
PMCPMC12107371

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.