Evidence map›Paper›PMID 40031101›Full record

ArticleBiochemical and biophysical research communications2025

Osteoprotegerin is induced by transforming growth factor-beta 1 and regulates pro-fibrotic responses in human dermal fibroblasts.

Aaron K McDowell-Sanchez, Alan R Waich Cohen, Santiago Sanchez, Konstantin Tsoyi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multi-omics reveals a novel Cxcr4Clinical and translational medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron K McDowell-SanchezSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Alan R Waich CohenSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Santiago SanchezSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Konstantin TsoyiSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: Konstantin.Tsoyi@bcm.edu.

Funding

Macropinocytosis and Pulmonary FibrosisR01HL176934 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Konstantin Tsoyi · 2025 to 2026
$1.2M
Antifibrotic effects of Syndecan-2 and CD148 in Rheumatoid Arthritis Interstitial Lung DiseaseK01AR074558 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI TSOYI, KONSTANTIN · 2020 to 2024
$655k
Contribution of Macropinocytosis in fibroblast activation and systemic sclerosisR21AR080332 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI TSOYI, KONSTANTIN · 2022 to 2023
$387k
NHLBI NIH HHS R01 HL176934NIAMS NIH HHS K01 AR074558NIAMS NIH HHS R21 AR080332
6 · The paper itself

Abstract

Transforming growth factor-beta1 (TGF-β1) is known to play a key role in the progression of organ fibrosis. Here, we demonstrate that TGF-β1 induces osteoprotegerin (OPG) expression in human dermal fibroblasts (HDFs) at both protein and mRNA levels. OPG neutralization has led to attenuation of TGF-β1-mediated profibrotic effects in HDFs. Further, we found that recombinant OPG induced fibronectin (FN) production and alpha-smooth muscle actin (α-SMA) expression. Interestingly, the OPG-mediated effect was significantly attenuated by αvβ3-integrin inhibitors (cyclo(RGDfK) and cilengitide) suggesting that OPG exerts profibrotic responses in human dermal fibroblasts by regulating αvβ3-integrin activation. Taken together, our data suggest that OPG expression is stimulated by TGF-β1 and contributes to dermal fibroblast activation.

Indexed as

FibroblastsOsteoprotegerinSkinTransforming Growth Factor beta1ActinsCells, CulturedFibronectinsFibrosisHumansIntegrin alphaVbeta3ActinsFibronectinsIntegrin alphaVbeta3OsteoprotegerinTNFRSF11B protein, humanTransforming Growth Factor beta1

Identifiers

PMID40031101
PMCPMC13282626

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.