Evidence map›Paper›PMID 40032274›Full record

ArticleMolecular pharmaceutics2025

Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment.

Léo Guilbaud, Cheng Chen, Inês Domingues, Espoir K Kavungere, Valentina Marotti, Hafsa Yagoubi, Wunan Zhang, Alessio Malfanti, Ana Beloqui

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  3. Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Léo GuilbaudLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.ORCID 0009-0007-3892-497X
Cheng ChenLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.
Inês DominguesLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.
Espoir K KavungereLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.
Valentina MarottiLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0002-7273-0868
Hafsa YagoubiLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.
Wunan ZhangLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.
Alessio MalfantiDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.ORCID 0000-0002-3694-8667
Ana BeloquiLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0003-4221-3357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Harnessing the effect of the cyclic GMP-AMP Synthase-STimulator of INterferon Genes (cGAS-STING) signaling pathway has emerged as a promising approach to developing novel strategies for the oral treatment of inflammatory bowel disease (IBD). In this work, we screened different cGAS-STING inhibitors

Indexed as

Inflammatory Bowel DiseasesLipidsMembrane ProteinsNucleotidyltransferasesAdministration, OralAnimalsColitisCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDextran SulfateDisease Models, AnimalHumansMacrophagesMiceMice, Inbred C57BLNanocapsulesNanomedicinecGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDextran SulfateLipidsMembrane ProteinsNanocapsulesNucleotidyltransferasesSting1 protein, mouseSTING ProteincGAS-STING pathwayGLP-2 secretioninflammatory bowel diseaselipid nanocapsulesmucosal healingre-epithelialization

Identifiers

PMID40032274
PMCPMC11979890

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.