ArticleGut2025
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T
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Article in Gut, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Bile acid signaling in health and disease.Molecular biomedicine · 2026Review
- Article
- Advancement of humanized mice and leading applications in immunological disease models.Inflammation and regeneration · 2026Review
- GGT-triggered self-immolative dexamethasone-oligopeptide prodrug nanoparticles ameliorate hepatic fibrosis via dual anti-inflammatory/immunomodulatory pathways with minimized systemic toxicity.Journal of nanobiotechnology · 2026Article
- The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism.Molecular metabolism · 2026Article
- The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders-From Mechanisms to Precision Therapeutics.Veterinary sciences · 2026Review
- The gut-liver axis modulates intestinal immune homeostasis.Mucosal immunology · 2026Review
- Integrating "Yang transforming Qi and Yin constituting the body" with immune regulation: an evidence synthesis of multidimensional traditional chinese medicine therapy for immune thrombocytopenia.Chinese medicine · 2026Review
- Microbial metabolic memory in inflammatory bowel disease: microbiota-derived metabolites, host-microbe reprogramming, and relapse susceptibility.Frontiers in microbiology · 2026Review
- Pleiotropic immunoregulation by bile acids in pathophysiology.Frontiers in immunology · 2026Review
- Interactions between the gut microbiota and immune cell dynamics: novel insights into the gut-bone axis.Gut microbes · 2025Review
- The history and future of bile acid therapies.Journal of hepatology · 2025Article
- Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease.Hepatology (Baltimore, Md.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Ci ZhuHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Nicole BoucheronInstitute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Osamah Al-RubayeInstitute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Brian K ChungDepartment of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
Liv Wenche ThorbjørnsenDepartment of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
Thomas KöcherVienna BioCenter Core Facilities, Metabolomics, Vienna BioCenter, Vienna, Austria.
Michael SchusterBiomedical Sequencing Facility, Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Thierry ClaudelHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Emina HalilbasicHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Victoria KunczerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Fanziska MuscateDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Lois L CavanaghInstitute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Darina WaltenbergerInstitute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Alexander LercherCemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Anna Ohradanova-RepicInstitute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Philipp SchatzlmaierInstitute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Tatjana StojakovicClinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Andreas BergthalerCemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Hannes StockingerInstitute for Hygiene and Applied Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Samuel HuberI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christoph BockBiomedical Sequencing Facility, Cemm, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Lukas KennerDivision of Experimental and Translational Pathology, Department of Pathology, Medical University of Vienna, Vienna, Austria.
Tom H KarlsenDepartment of Transplantation Medicine, Clinic of Surgery and Specialized Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.ORCID 0000-0002-8289-9931
Wilfried EllmeierInstitute of Immunology, Center for Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria michael.trauner@meduniwien.ac.at wilfried.ellmeier@meduniwien.ac.at.
Michael TraunerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria michael.trauner@meduniwien.ac.at wilfried.ellmeier@meduniwien.ac.at.ORCID 0000-0002-1275-6425
Funding
No grant is acknowledged in the PubMed record.
Abstract
background24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC).
objectiveSince PSC strongly associates with T helper-type-like 17 (T
designNorUDCA's impact on T
resultsNorUDCA suppressed T
conclusionNorUDCA restricts T
Indexed as
Cell TransdifferentiationCholangitis, SclerosingTh17 CellsUrsodeoxycholic AcidAdoptive TransferAnimalsCell DifferentiationDisease Models, AnimalHumansInterleukin-17Mice24-norursodeoxycholic acidInterleukin-17Ursodeoxycholic AcidAUTOIMMUNE LIVER DISEASEBILE ACIDINFLAMMATORY BOWEL DISEASEINTESTINAL T CELLSPRIMARY SCLEROSING CHOLANGITIS
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.