Evidence map›Paper›PMID 40033348›Full record

ArticleBMC research notes2025

Morphological characteristics of microenvironment in the human thymus during fetal development.

Nemanja Maletin, Nikola Denda, Stefan Borocki, Zoran Golušin, Aleksandar Rašković, Aleksandra Fejsa-Levakov, Bojana Andrejić Višnjić, Jelena Amidžić

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nemanja MaletinFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia. 910070d24@mf.uns.ac.rs.ORCID http://orcid.org/0009-0009-8592-0685
Nikola DendaFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Stefan BorockiFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Zoran GolušinFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID http://orcid.org/0000-0003-4603-0080
Aleksandar RaškovićFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID http://orcid.org/0000-0001-8439-4630
Aleksandra Fejsa-LevakovFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID http://orcid.org/0000-0002-9510-3090
Bojana Andrejić VišnjićFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID http://orcid.org/0000-0001-6810-9190
Jelena AmidžićFaculty of Medicine, University of Novi Sad, Novi Sad, Serbia.ORCID http://orcid.org/0000-0001-6146-2346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe thymus is a key organ for the development of T cells. T cell precursors first migrate from the bone marrow to the thymus. During maturation, these precursors require interactions with various types of cells that form the thymic microenvironment, such as epithelial, mesenchymal, and other immune cells not belonging to the T lineage. The aim of this study was to examine the changes in the number and diameter of Hassall's corpuscles, as well as the density and distribution of epithelial cells (p63+) and macrophages (CD68+).

methodsTwenty-five fetal thymus samples were examined, divided into five groups according to gestational age. The samples were processed using standard histological methods and immunohistochemical staining.

resultsThe study showed that the number and diameter of Hassall's corpuscles gradually increased during fetal development, with a significant increase from the 14th to the 38th gestational week. The average diameter of Hassall's corpuscles was largest in the age group of 34-38 weeks. The density of p63 + epithelial cells decreased in correlation with gestational week, while the density of CD68 + macrophages significantly increased, particularly in the thymic medulla, towards the end of the fetal period.

conclusionsAn increase in the number and size of Hassall's corpuscles during fetal development was recorded, while the density of epithelial cells decreased and the density of macrophages increased.

Indexed as

Cellular MicroenvironmentFetal DevelopmentThymus GlandAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeEpithelial CellsFemaleFetusGestational AgeHumansMacrophagesPregnancyAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 MoleculeEpithelial cellsHassall's corpusclesMacrophagesThymus

Identifiers

PMID40033348
PMCPMC11877800

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.