ArticleAnnals of clinical and translational neurology2025
Dual-Phase C-11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Positron emission tomography for diagnosing cerebrovascular disorders: a scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundCerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual-phase
methodsWe prospectively enrolled patients with probable CAA for dynamic PiB and AV1451 scans. We compared early-phase (0-6 min after tracer injection) and late-phase (40-70 min) PiB PET between the tau(+) and tau(-) groups (based on AV1451 PET) and investigated their diagnostic values for detecting tau.
resultsCAA/tau(+) had lower early-phase temporal PiB uptake than CAA/tau(-) (p = 0.014) and higher late-phase uptake in the whole cortex and temporal and parietal lobes (all p < 0.05). Early-phase temporal PiB SUVR correlated with tau burden (r = -0.34, p = 0.038). Using Youden's cut-off, early-phase and late-phase PET had sensitivities of 55% and 80% and specificities of 85% and 65% for detecting tau, respectively. Combining early- and late-phase scans provided a rule-out sensitivity of 90% and rule-in specificity of 100% for tau pathology in CAA.
conclusionsDual-phase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.