Evidence map›Paper›PMID 40033964›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Nanopore-Functionalized Hybrid Lipid-Block Copolymer Membranes Allow Efficient Single-Molecule Sampling and Stable Sensing of Human Serum.

Edo Vreeker, Fabian Grünewald, Nieck Jordy van der Heide, Andrea Bonini, Siewert J Marrink, Katarzyna Kasia Tych, Giovanni Maglia

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Photocatalytic Biohybrid Vesicles.Chemical reviews · 2026
    Review
  4. Accessing robust vaccine coformulation stability by single adjuvant detection on a microelectrode.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edo VreekerGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0000-0003-4198-6745
Fabian GrünewaldGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0000-0002-1889-8029
Nieck Jordy van der HeideGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0009-0009-2592-5206
Andrea BoniniGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0000-0001-9511-0699
Siewert J MarrinkGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0000-0001-8423-5277
Katarzyna Kasia TychGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0000-0001-9091-0507
Giovanni MagliaGroningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen, 9747 AG, The Netherlands.ORCID https://orcid.org/0000-0003-2784-0811

Funding

Designed nanopores for single-molecule protein sequencingR01HG012554 · NHGRI · GRONINGEN UNIVERSITY · PI MAGLIA, GIOVANNI · 2022 to 2024
$1.3M
Netherlands Organization for International Cooperation in Higher Education VICI VI.C.192.068NHGRI NIH HHS 1R01HG012554-01NHGRI NIH HHS R01 HG012554
6 · The paper itself

Abstract

Biological nanopores are powerful tools for single-molecule detection, with promising potential as next-generation biosensors. A major bottleneck in nanopore analysis is the fragility of the supporting lipid membranes, that easily rupture after exposure to biological samples. Membranes comprising PMOXA-PDMS-PMOXA (poly(2-methyloxazoline-b-dimethylsiloxane-b-2-methyloxazoline)) or PBD-PEO (poly(1,2-butadiene)-b-poly(ethylene oxide)) polymers may form robust alternatives, but their suitability for the reconstitution of a broad range of nanopores has not yet been investigated. Here, PBD-PEO membranes are found to be highly robust toward applied voltages and human serum, while providing a poor environment for nanopore reconstitution. However, hybrid membranes containing a similar molar ratio of PBD

Indexed as

Biosensing TechniquesLipidsNanoporesPolymersSerumHumansMolecular Dynamics SimulationPolyethylene GlycolsLipidsPolyethylene GlycolsPolymersbiological nanoporeselectrophysiologyhybrid membranesMD simulations

Identifiers

PMID40033964
PMCPMC12004896

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.