ArticleOsteoarthritis and cartilage open2025
The associations between sleep problems and pain outcomes in people with hand osteoarthritis - Data from the Nor-hand study.
Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Sleep quality in pregnant women with lumbopelvic pain: prevalence of clinically significant sleep disturbance and comparison in clinical outcomes between pregnant women with and without clinically significant sleep disturbance.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- The severity of depressive symptoms as a mediator in the sleep-osteoarthritis risk pathway: insights from the ELSA cohort.Frontiers in nutrition · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Objective: To examine the relation of sleep problems to pain outcomes in people with hand osteoarthritis, and the extent to which central sensitization mediates these relationships. Design: In total 299 participants from the Nor-Hand cohort study rated their sleep problems (no, slight, moderate or severe problems), hand pain intensity on a Numeric Rating Scale (NRS, range: 0-10) and Australian/Canadian Osteoarthritis Hand Index (AUSCAN; range: 0-20), and overall bodily pain intensity (NRS). Central sensitization was evaluated by quantitative sensory testing. All pain questionnaires were repeated after 3.5 years. We explored the associations between sleep problems at baseline and pain outcomes at baseline and follow-up and fitted natural effect models to examine the extent to which measures of central sensitization mediated the effects of sleep problems on pain. All main analyses were adjusted for age, sex, education, comorbidities, and body mass index. Results: Slight, moderate, and severe sleep problems were reported by 33.8 %, 26.8 % and 14.3 %, respectively. In general, individuals with severe versus without sleep problems reported relatively more intense pain at baseline and follow up (i.e., a 1.68 (95 % confidence interval 0.89-2.46) higher NRS hand pain at baseline). Associations between sleep and central sensitization were weak, with no mediating effects found. For example, the indirect effect of remote pressure pain thresholds was 0.06 (-0.27, 0.39) NRS points for hand pain among individuals reporting severe sleep problems. Conclusion: Sleep problems are commonly reported and related to pain intensity in people with hand osteoarthritis, while the underlying mechanisms and temporal relationship remain unclear.
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