SynthesisThe clinical respiratory journal2025
Changes in Retinal Nerve Fiber Layer Thickness in Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Synthesis in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Diagnostic value of ocular imaging biomarkers in chronic obstructive pulmonary disease: a multicenter prospective cross-sectional study.Journal of thoracic disease · 2026Article
- Analysis of factors influencing retinal thickness in chronic obstructive pulmonary disease and hypertension: a cross-sectional study in a community-dwelling middle-aged and elderly population.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeThe purpose of this study is to evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and the onset as well as progression of chronic obstructive pulmonary disease (COPD).
methodsDatabase searches were conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Data, VIP Database, and CBM, covering the period from each database's inception to March 2024.
resultsThis meta-analysis included 15 studies from 2016 to 2023, comprising a total of 1455 participants (801 in the COPD group and 654 in the health group). The results showed a significant reduction in RNFL thickness across all quadrants (average, inferior, nasal, superior, and temporal) in the COPD group compared to the health group (MD: -4.46; 95%CI: -7.77 to -1.14; p = 0.008; MD: -8.17; 95%CI: -11.36 to -4.99; p < 0.00001; MD: -4.69; 95%CI: -7.22 to -2.16; p = 0.0003; MD: -4.83; 95%CI: -8.45 to -1.21; p = 0.009; MD: -2.89; 95%CI: -5.35 to -0.43; p = 0.02). In the mild/moderate COPD group, only the inferior RNFL (MD: -2.32; 95%CI: -4.40 to -0.24; p = 0.03) showed a significant reduction. However, in the severe COPD group, all quadrants were significantly reduced (MD: -5.89; 95%CI: -7.40 to -4.38; p < 0.0001; MD: -6.74; 95%CI: -10.71 to -2.77; p = 0.0009; MD: -4.29; 95%CI: -5.95 to -2.64; p < 0.0001; MD: -2.34; 95%CI: -4.30 to -0.37; p = 0.02; MD: -4.84; 95%CI: -8.82 to -0.86; p = 0.02).
conclusionBased on current evidence, the average RNFL thickness and the thicknesses of various RNFL regions in COPD patients are significantly lower than those in healthy subjects, and these reductions are closely associated with disease severity. The inferior RNFL may be the first to show changes with the onset and progression of COPD.
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