ArticleJournal of cosmetic dermatology2025
The Causal Relationship Between Acne Vulgaris and BMI: A Mendelian Randomization Study.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Identification and Validation of Iron Metabolism-Related Biomarkers in Endometriosis: A Mendelian Randomization and Single-Cell Transcriptomics Study.Current issues in molecular biology · 2025Article
- Investigating the Impact of Circulating Immune Cells on Acne Using Mendelian Randomization.Clinical, cosmetic and investigational dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundAs an inflammatory skin condition, acne usually presents with a complex pathogenesis. Recent studies suggest that BMI may relate to the incidence of acne. Mendelian randomization is a statistical method that is used to evaluate the causal effects of exposure factors on outcome variables.
methodsWe applied the inverse-variance weighted (IVW) method to evaluate the causal effect as the primary analysis between BMI and acne in our two-sample Mendelian randomization study. We included 58 SNPs accounting for 2.5% (R
resultThe F-statistic obtained from the first stage of the MR regression model was 61. Importantly, the results from all three methods consistently indicated that an increase in BMI did not elevate the risk of acne, with each result reaching statistical significance. Cochran's Q test revealed no evidence of heterogeneity among the IV estimates for individual variants. Our I
conclusionOur findings suggested that there is no causal relationship between BMI and acne.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.