Evidence map›Paper›PMID 40035294›Full record

ArticleCNS neuroscience & therapeutics2025

Characteristics of Cerebral Autoregulation After Mechanical Thrombectomy and Its Relationship With Prognosis.

Yang Qu, Menglu Cong, Jia Liu, Pan-Deng Zhang, Zi-Duo Shen, Han Zhang, Yingying Sun, Hongjing Zhu, Chao Li, Peng Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yang QuStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Menglu CongStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Jia LiuLaboratory for Engineering and Scientific Computing, Institute of Advanced Computing and Digital Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Pan-Deng ZhangLaboratory for Engineering and Scientific Computing, Institute of Advanced Computing and Digital Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Zi-Duo ShenStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Han ZhangStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Yingying SunStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Hongjing ZhuStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Chao LiStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Peng ZhangStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.ORCID 0000-0001-5536-0255
Junlei ChangCenter for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0002-0319-9022
Kejia ZhangStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Jiaxin RenStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Hang JinStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Xin SunStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.ORCID 0009-0008-7483-7766
Yi YangStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Zhen-Ni GuoStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.

Funding

Jilin Provincial Key Laboratory YDZJ202302CXJD017Talent Reserve Program of the First Hospital of Jilin University JDYYCB-2023002The National Natural Science Foundation of China 82271303The Norman Bethune Health Science Center of Jilin University 2022JBGS03The Science and Technology Department of Jilin Province 20220303002SF;YDZJ202302CXJD061The Science and Technology Department of Jilin Province YDZJ202201ZYTS677
6 · The paper itself

Abstract

aimsTo investigate the characteristics of dynamic cerebral autoregulation (dCA) in patients after mechanical thrombectomy (MT) and the relationship between dCA and prognosis.

methodsIn this prospective study, 89 and 158 patients were enrolled in the MT and non-MT groups, respectively. Both groups underwent dCA measurements within 3 days after stroke. The transfer function parameter, phase difference (PD), and gain were used to quantify dCA. A favorable outcome was defined as a modified Rankin Scale score ≤ 2 at 90 days. The collateral score was used to reflect the collateral reserve capacity.

resultsMT was associated with better PD in both the affected and unaffected sides. In the MT group, the PD of the affected side was an independent predictor of favorable outcomes (odds ratio [OR] 0.927, 95% confidence interval [CI] 0.885-0.970; p < 0.001). The area under the receiver operating characteristic curve for predicting favorable outcomes of the PD on the affected side was 0.759 (95% CI, 0.654-0.864; p < 0.001). Further, good collaterals were independently associated with better PD.

conclusionsMT has a positive effect on dCA during the acute phase of stroke. For patients undergoing MT, dCA is a reliable indicator for predicting prognosis and may be an intervention target to improve outcomes.

Indexed as

Cerebrovascular CirculationHomeostasisIschemic StrokeStrokeThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisProspective StudiesTreatment Outcomecerebral autoregulationcollateral circulationmechanical thrombectomyprognosisrevascularizationstroke

Identifiers

PMID40035294
PMCPMC11877133

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.