Evidence map›Paper›PMID 40035902›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Pea Peptides and Heavy Metal Neurotoxicity: Exploring Mechanisms and Mitigation Strategies in PC12 Cells.

Ning Li, Ningning Cui, Tiange Li, Peijun Zhao, Ibrahim A Bakry, Qian Li, Yongxia Cheng, Gianni Galaverna, Huijie Yang, Fangyu Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ning LiCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China. ln8028@163.com.
Ningning CuiCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Tiange LiCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Peijun ZhaoCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Ibrahim A BakryCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Qian LiCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Yongxia ChengCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Gianni GalavernaKey Laboratory for Animal Immunology, Henan Academy of Agricultural Sciences, 116# Huayuan Road, Zhengzhou, 450002, PR China.
Huijie YangCollege of Food Science and Technology, Henan Agricultural University, 63# Agricultural Road, Zhengzhou, 450000, China.
Fangyu WangKey Laboratory for Animal Immunology, Henan Academy of Agricultural Sciences, 116# Huayuan Road, Zhengzhou, 450002, PR China. sprinkle.w@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calsyntenin-1 (Clst1) is a sensitive indicator of lead (Pb) toxicity in neural tissue. This study was designed to investigate the impact of lead exposure on Clst1 expression in PC12 cells and the mitigating effect of pea peptide 4 (PP4) on lead-induced neurotoxicity. Data showed that lead exposure, at varying doses and durations, disrupted the mRNA expression and protein levels of Clstn1 in PC12 cells. However, immunofluorescence results showed that treatment with PP4 significantly increased Clstn1 protein expression in the Pb + PP4 and PP4 groups compared to the Pb groups (P < 0.05). Lead exposure activates the JNK and p38 pathways; at the same time, PP4 treatment enhances ERK pathway activation and reduces JNK and p38 activation.

Indexed as

Calcium-Binding ProteinsLeadMetals, HeavyNeurotoxicity SyndromesPea ProteinsPeptidesPisum sativumAnimalsMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesPC12 CellsRatsRNA, MessengerCalcium-Binding ProteinsLeadMetals, Heavyp38 Mitogen-Activated Protein KinasesPea ProteinsPeptidesRNA, MessengerAlzheimer's diseaseCalsyntenin-1LeadPC12Pea peptide

Identifiers

PMID40035902

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.