Evidence map›Paper›PMID 40035949›Full record

ArticleMolecular neurobiology2025

CDC42 Regulates the ERK Pathway to Improve Oxygen‒Glucose Deprivation/Reoxygenation-Induced Neural Oxidative Stress and Apoptosis.

Lina Hao, Hongmei Jia, Feifei Wei, Junbo Zhang, Jian Zhang, Chunying Guo, Liying Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lina HaoFunctional Department, CangZhou Hospital of Integrated TCM-WM HEBEI, Cangzhou, 061001, China.
Hongmei JiaFunctional Department, Hengshui Third People's Hospital, No.7 Chengji Road, Hengshui, 053000, China.
Feifei WeiFunctional Department, Hengshui Third People's Hospital, No.7 Chengji Road, Hengshui, 053000, China. suwei42400771320@163.com.
Junbo ZhangInternal Medicine Department, Dacheng County Hospital, Langfang, 065900, China.
Jian ZhangInternal Medicine-Neurology, Dacheng County Hospital, Langfang, 065900, China.
Chunying GuoFunctional Department, CangZhou Hospital of Integrated TCM-WM HEBEI, Cangzhou, 061001, China.
Liying WangFunctional Department, CangZhou Hospital of Integrated TCM-WM HEBEI, Cangzhou, 061001, China.

Funding

Medical Sciences Research Program of Hebei Province No. 20211777
6 · The paper itself

Abstract

CDC42 regulates neural morphology, differentiation, and injury and modifies oxidative stress and neural immune infiltration, but its effect on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neural injury has not been reported. Therefore, this study aimed to investigate the effects of CDC42 overexpression on neural injury and oxidative stress during the OGD/R process. The OGD/R cellular model was established by culturing HT22 cells in glucose-free medium under hypoxic conditions for 2, 4, or 6 h and then transferring them to complete medium and a standard environment for another 24 h. CDC42 and negative control overexpression vectors (oeCDC42 and oeNC) were transfected into HT22 cells; afterwards, PD98059, a specific ERK inhibitor, was added along with or without oeCDC42. CDC42 expression, cell viability, and superoxide dismutase (SOD) activity were reduced, but cell apoptosis and reactive oxygen species (ROS) were elevated after OGD/R induction in a time-dependent manner. oeCDC42 decreased cell apoptosis and ROS and increased SOD activity in OGD/R-induced HT22 cells, but it did not significantly increase cell viability. Moreover, oeCDC42 positively regulated p-ERK and p-c-Fos expression. In addition, PD98059 decreased cell viability and SOD activity but increased cell apoptosis and ROS in OGD/R-induced HT22 cells; moreover, the effects of PD98059 combined with oeCDC42 also showed similar trends compared to oeCDC42 alone regarding the above indexes. CDC42 can ameliorate OGD/R-induced neural oxidative stress and apoptosis by regulating the ERK pathway.

Indexed as

Apoptosiscdc42 GTP-Binding ProteinGlucoseMAP Kinase Signaling SystemNeuronsOxidative StressOxygenAnimalsCell HypoxiaCell LineCell SurvivalFlavonoidsMiceReactive Oxygen SpeciesSuperoxide Dismutasecdc42 GTP-Binding ProteinFlavonoidsGlucoseOxygenReactive Oxygen SpeciesSuperoxide DismutaseCDC42ERK pathwayNeural apoptosisNeural oxidative stressOxygen–glucose deprivation/reoxygenation

Identifiers

PMID40035949

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.