Evidence map›Paper›PMID 40036868›Full record

ArticleMolecular biology and evolution2025

Cross-Species Insights from Single-Nucleus Sequencing Highlight Aging-Related Hippocampal Features in Tree Shrew.

Liu-Lin Xiong, Rui-Ze Niu, Li Chen, Li-Ren Huangfu, Jing Li, Lu-Lu Xue, Yi-Fei Sun, Li-Mei Wang, Yong-Ping Li, Jia Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liu-Lin XiongDepartment of Neurosurgery, Institute of Neurological Disease, National-Local Joint Engineering Research Center of Translational Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.ORCID 0000-0002-1623-5969
Rui-Ze NiuScience and Education Department, Mental Health Center of Kunming Medical University, Kunming 650034, Yunnan, China.ORCID 0000-0002-7022-6430
Li ChenDepartment of Neurosurgery, Institute of Neurological Disease, National-Local Joint Engineering Research Center of Translational Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.ORCID 0000-0001-8628-7708
Li-Ren HuangfuInstitute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan, China.ORCID 0009-0002-5962-3205
Jing LiInstitute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan, China.ORCID 0009-0006-6240-6921
Lu-Lu XueState Key Lab of Biotherapy, Sichuan University, Chengdu 610041, Sichuan, China.ORCID 0000-0001-5253-7158
Yi-Fei SunInstitute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan, China.ORCID 0000-0001-6309-4655
Li-Mei WangInstitute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan, China.ORCID 0000-0002-1753-6958
Yong-Ping LiInstitute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan, China.ORCID 0009-0007-4794-4198
Jia LiuInstitute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan, China.ORCID 0000-0001-5678-7437
Ting-Hua WangDepartment of Neurosurgery, Institute of Neurological Disease, National-Local Joint Engineering Research Center of Translational Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.ORCID 0000-0003-2012-8936

Funding

First People's Hospital of ZunyiFuture Talent Training Program-Technology Elite ZYSE-2021-03Guizhou Province Distinguished Young Scientific and Technological Talent Program YQK[2023]040Guizhou Provincial Higher Education Science and Technological Innovation Team [2023]072Kunming Health Science and Technology Talent Training ProjectNational Natural Science Foundation of China 82001604Talent Research StartupYunnan Education Department Fund 2025J0246Yunnan Provincial Science and Technology Talent and Platform Program 202205AF150013Zunyi Medical University
6 · The paper itself

Abstract

The tree shrew brain has garnered considerable attention due to its remarkable similarities to human brain. However, the cellular composition and genetic signatures of tree shrew hippocampus across postnatal life remain poorly characterized. Here, we establish the first single-nucleus transcriptomic atlas of tree shrew hippocampus spanning postnatal life, detailing the dynamics and diversity of the neurogenic lineage, oligodendrocytes, microglia, and endothelial cells. Notably, cross-species transcriptomic comparison among humans, macaques, tree shrews, and mice reveals that the tree shrew transcriptome resembles that of macaques, making it a promising model for simulating human neurological diseases. More interestingly, we identified a unique class of tree shrew-specific neural stem cells and established SOX6, ADAMTS19, and MAP2 as their markers. Furthermore, aberrant gene expression and cellular dysfunction in the tree shrew hippocampus are linked to neuroinflammation and cognitive impairment during tree shrew aging. Our study provides extensive resources on cell composition and transcriptomic profiles, serving as a foundation for future research on neurodevelopmental and neurological disorders in tree shrews.

Indexed as

AgingHippocampusTranscriptomeTupaiidaeAnimalsHumansMiceagingcross-speciesneural stem cellssingle-nucleus RNA sequencingtree shrew

Identifiers

PMID40036868
PMCPMC11879083

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.