Evidence map›Paper›PMID 40037067›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2025

Antagonism of the antinociceptive effects of fentanyl and the veterinary anesthetic xylazine in mice.

Kerim Cakir, Jumar Etkins, Mariah L Nguyen, Karen Gonzalez, Gabriel Enrique Vivas Casanova, Ellen A Walker

Abstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kerim CakirDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania.
Jumar EtkinsDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania.
Mariah L NguyenDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania.
Karen GonzalezDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania.
Gabriel Enrique Vivas CasanovaDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania.
Ellen A WalkerDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, Pennsylvania; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania. Electronic address: ellen.walker@temple.edu.

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI SCOTT M. RAWLS · 2000 to 2026
$34.6M
NIDA NIH HHS P30 DA013429
6 · The paper itself

Abstract

A recent twist to the ongoing tragedy of the opioid epidemic is the adulteration of fentanyl with the veterinary tranquilizer xylazine, an α

Indexed as

AnalgesicsAnalgesics, OpioidFentanylXylazineAdrenergic alpha-2 Receptor AntagonistsAnimalsDose-Response Relationship, DrugFemaleMaleMiceNaltrexoneYohimbineAdrenergic alpha-2 Receptor AntagonistsAnalgesicsAnalgesics, OpioidFentanylNaltrexoneXylazineYohimbineFentanylHaloperidolIdazoxanNaltrexoneXylazineYohimbine

Identifiers

PMID40037067
PMCPMC13095407

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.