Evidence map›Paper›PMID 40037396›Full record

SynthesisRenal failure2025

Kidney function and cognitive impairment: a systematic review and meta-analysis.

Xiaohua Pei, Nazia Begum Bakerally, Zhan Wang, Yun Bo, Yao Ma, Zhenzhu Yong, Sizhu Zhu, Fei Gao, Zhu Bei, Weihong Zhao

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Observational
  11. Review
  12. The role of per- and polyfluoroalkyl substances in cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaohua PeiDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Nazia Begum BakerallyDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhan WangDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Yun BoDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yao MaDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhenzhu YongDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Sizhu ZhuDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Fei GaoDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhu BeiDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Weihong ZhaoDepartment of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA worldwide evaluation exploring the link between a broad-spectrum kidney function and cognitive impairment (CI) prevalence, and related risk factors has yet to be conducted.

methodsStudies published before November 2024 were retrieved from PubMed and Web of Science. R software (R Foundation for Statistical Computing, Vienna, Austria) and Review Manager (Cochrane Collaboration, London, UK) were used to analyze the relationship of CI with various estimated glomerular filtration rate (eGFR) level and the associated risk factors. A random model effect was adopted for a heterogeneity (

resultsSeventeen (involving 32,141 participants) out of 5892 studies were included. The MMSE and MoCA were the most commonly used tests to assess cognitive function. The prevalence of CI raised significantly with declining kidney function: 10% for eGFR ≥60 mL/min/1.73 m

conclusionsThe poorer the renal function, the higher the prevalence rate of CI. Patients with chronic kidney disease (CKD) have multiple risk factors that lead to CI.

Indexed as

Cognitive DysfunctionGlomerular Filtration RateKidneyRenal Insufficiency, ChronicHumansPrevalenceRisk FactorsAgedementiaglomerular filtration ratekidney function

Identifiers

PMID40037396
PMCPMC11881663

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.