Observational studyEuropean heart journal. Cardiovascular Imaging2025
Effect of statin therapy on coronary inflammation assessed by pericoronary adipose tissue computed tomography attenuation.
Observational study in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Difference of pericoronary adipose tissue attenuation between culprit and non-culprit lesions in acute coronary syndrome: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Statin Effects on Pericoronary Adipose Tissue Density in People With HIV: Insights From the REPRIEVE Trial.JACC. Cardiovascular imaging · 2026Trial
- Association of Relative Pericoronary Adipose Tissue Attenuation with Coronary Artery Calcification Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Targeting perivascular adipose tissue in vascular aging: innovative translational strategies for disease prevention and monitoring.Apoptosis : an international journal on programmed cell death · 2026Review
- Computed Tomography-Based Radiomics Provides New Insights Into Associations Between Pericoronary Fat Characteristics and Low-Density Lipoprotein Cholesterol.Reviews in cardiovascular medicine · 2026Article
- Pericoronary Adipose Tissue Attenuation in Patients with Spontaneous Coronary Artery Dissection According to Emotional Versus Physical Triggers: An Analysis from the INSIGHT-SCAD Study.Journal of cardiovascular development and disease · 2026Article
- "Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk".Frontiers in cardiovascular medicine · 2026Article
- High-intensity statin therapy is associated with reduced coronary inflammation on CT in patients with type 2 diabetes mellitus.Diabetes, obesity & metabolism · 2025Article
- Serial Coronary CTA for Monitoring Response to Lipid-Lowering Therapy: A Narrative Review.Current atherosclerosis reports · 2025Review
- Computed tomography-based assessment of pericoronary adipose tissue in cardiovascular diseases: Diagnostic and prognostic implications.World journal of radiology · 2025Review
- Pericoronary adipose tissue inflammation mediates the atherogenic effects of lipids on multivessel coronary artery disease: a CCTA-based radiomics analysis.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimsPericoronary adipose tissue (PCAT) attenuation on coronary computed tomography angiography (CCTA) is an imaging biomarker of coronary inflammation. The natural history of PCAT attenuation remains unknown. High-intensity statin therapy has pleiotropic anti-inflammatory effects. We sought to assess temporal changes in PCAT attenuation in patients with and without statin therapy. METHODS AND
resultsThis was a multicentre observational study that included consecutive patients with stable coronary artery disease (CAD) undergoing clinically indicated serial CCTA with identical scan parameters ≥ 12 months apart between May 2013 and July 2022. Using semi-automated software, PCAT attenuation was measured on a per-lesion level (PCATlesion) and per-patient level around the proximal right coronary artery (PCATRCA). Of the 96 patients (57 ± 11 years, 60% male), 34 patients were not on a statin at baseline or follow-up (statin-naive), 26 patients were commenced on a statin after the baseline scan (statin-commenced), and 34 patients were on a statin at both time points (statin-continued). There was no significant difference between the groups for age, sex, body mass index (BMI), and prevalence of traditional cardiovascular risk factors except for dyslipidaemia (25.0% vs. 34.6% vs. 64.7%, P < 0.01 for trend). At a median follow-up of 3.8 years, there was a significant reduction in PCATlesion in the statin-commenced (-79.4 ± 11.7 to -86.5 ± 10 HU, P < 0.001) and the statin-continued (-83.5 ± 8.5 to -90.6 ± 8.5 HU, P = 0.001) groups. Meanwhile, no significant difference in PCATlesion was observed in the statin-naïve group (-84.4 ± 9.7 to -86.6 ± 9.5, P = 0.1). Multivariate analysis showed statin intensity and LDL change to be independently associated with percentage change of PCATlesion, after correcting for cardiovascular risk factors, changes in body weight, and coronary artery calcium score.
conclusionStatin therapy was associated with a reduction in PCATlesion, while no significant change in PCATlesion was observed without statin therapy. If validated in larger studies, PCAT attenuation could potentially be used to monitor the response of the coronary arteries to statins and guide treatment.
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