Evidence mapPaperPMID 40037618Full record

ReviewThe oncologist2025

Management of vasomotor symptoms in cancer patients.

Ling Zhu, Tammy T Hshieh, Tara K Iyer, Alicia K Morgans, Ole-Petter R Hamnvik

Abstract readReview
In one paragraph

Review in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ling ZhuDepartment of Endocrinology, Singapore General Hospital, Singapore 169856.ORCID 0000-0001-9594-8467
Tammy T HshiehDivision of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States.
Tara K IyerMenopause and Midlife Clinic, Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, United States.
Alicia K MorgansLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, United States.
Ole-Petter R HamnvikDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States.ORCID 0000-0002-3600-2628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many cancer treatments can lead to reduced levels of sex hormones, which in turn may cause vasomotor symptoms (VMS) such as hot flashes. These symptoms are associated with impaired quality of life, as well as suboptimal tolerability of and adherence to cancer treatment. Hormone therapy, performed by increasing estradiol or testosterone levels, is the gold standard for treatment of VMS. However, this approach is generally contraindicated in patients with hormone-sensitive cancers. Nonhormone agents with low to moderate efficacy in controlling VMS are available, but their use may be limited by side effects and tolerability. In this narrative review, the approach to VMS in cancer patients will be discussed. The evidence for various treatment options, including novel agents such as fezolinetant that target the hypothalamic thermoregulatory pathway, will be evaluated. Finally, special considerations in different patient populations based on cancer types (eg, breast, prostate) and age groups (eg, older adults) will be explored.

Indexed as

Hot FlashesNeoplasmsVasomotor SystemFemaleHumansMaleQuality of Lifebreast cancercancer survivorshot flashesmenopauseprostate cancer

Identifiers

PMID40037618
PMCPMC11879400

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.