Evidence map›Paper›PMID 40038128›Full record

ArticleCurrent microbiology2025

Antifungal Action of Valencene and Nootkatone Compounds in Association with Fluconazole and Their Mechanism of Action Against Candida spp. and Pichia kudriavzevii Strains.

Joara Nályda Pereira Carneiro, Antonia Thassya Lucas Dos Santos, Victor Juno Alencar Fonseca, Maria Audilene de Freitas, Francildo Dos Santos Silva, Larissa Alves Lopes de Souza, Nadine Monteiro Salgueiro Araújo, Daniele de Oliveira Bezerra de Sousa, Rafael Guimarães Gomes Silva, João Xavier da Silva Neto and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Advancing the Understanding of the Mo-CBPProbiotics and antimicrobial proteins · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joara Nályda Pereira CarneiroCariri Applied Mycology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil.
Antonia Thassya Lucas Dos SantosCariri Applied Mycology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil.
Victor Juno Alencar FonsecaCariri Applied Mycology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil.
Maria Audilene de FreitasCariri Applied Mycology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil.
Francildo Dos Santos SilvaCariri Applied Mycology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil.
Larissa Alves Lopes de SouzaPlant Toxin Laboratory, Federal University of Ceara, Fortaleza, Ceara, Brazil.
Nadine Monteiro Salgueiro AraújoPlant Toxin Laboratory, Federal University of Ceara, Fortaleza, Ceara, Brazil.
Daniele de Oliveira Bezerra de SousaPlant Toxin Laboratory, Federal University of Ceara, Fortaleza, Ceara, Brazil.
Rafael Guimarães Gomes SilvaPlant Toxin Laboratory, Federal University of Ceara, Fortaleza, Ceara, Brazil.
João Xavier da Silva NetoBiotecnology and Molecular Biology Laboratory, State University of Ceara, Fortaleza, Ceara, Brazil.
Irwin Rose Alencar de MenezesLaboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri, Crato, Ceara, Brazil.
Henrique Douglas Melo CoutinhoMicrobiology and Molecular Biology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil. hdmcoutinho@gmail.com.
Maria Flaviana Bezerra Morais-BragaCariri Applied Mycology Laboratory, Regional University of Cariri, Crato, Ceara, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candidemia is a public health challenge as it causes thousands of annual deaths and combating it has become difficult due to the development of resistance in Candida spp. Compounds derived from natural products may counter this resistance. Therefore, we evaluate the intrinsic and combined antifungal activity of valencene and nootkatone compounds and their possible mechanism of action against Candida spp. Using the microdilution method, the antifungal effect of sesquiterpenes and their combination with fluconazole was determined. The results comprised the yeast growth curve and its 50% Inhibitory Concentration (IC

Indexed as

Antifungal AgentsCandidaFluconazolePichiaPolycyclic SesquiterpenesSesquiterpenesDrug SynergismMicrobial Sensitivity TestsAntifungal AgentsFluconazolenootkatonePolycyclic SesquiterpenesSesquiterpenesvalencene

Identifiers

PMID40038128

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.