Evidence map›Paper›PMID 40038798›Full record

Trial reportBrain and behavior2025

Changes in EEG Microstate Dynamics and Cognition Post-Chemotherapy in People With Breast Cancer.

S Damji, S Sattari, K Zadravec, K L Campbell, J Brunet, N Virji-Babul

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03277898 (Aerobic Exercise and Cognitive Functioning in Women With Breast Cancer), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03277898 naunknown statusnot on this map

Aerobic Exercise and Cognitive Functioning in Women With Breast Cancer: the ACTIVATE Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2017 to 2022Enrolled84ConditionsBreast NeoplasmsArmsAerobic Exercise, Usual Care (Wait-list Control)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S DamjiGraduate Program in Neuroscience, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
S SattariGraduate Program in Biomedical Engineering, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
K ZadravecGraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
K L CampbellDepartment of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
J BrunetSchool of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.
N Virji-BabulDepartment of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-8984-5848

Funding

AVON Foundation for WomenCanadian Cancer Society Research Institute 705382
6 · The paper itself

Abstract

objectiveChemotherapy-related cognitive changes following breast cancer are commonly reported; however, changes in brain dynamics of large-scale neural networks remain unclear. Using data from the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial, we conducted exploratory analyses to compare self-reported and objective measures of cognition and applied microstate analysis to resting state (RS) electroencephalography (EEG) data of women with breast cancer before and following chemotherapy treatment.

methodsData from eight female participants between the ages of 30 and 52 (mean age = 44.8 years, SD = 7.3 years) were analyzed. Cognitive function was assessed using the PROMIS (Patient-Reported Outcomes Measurement Information System) and the Trail Making Test (TMT). Five minutes of RS eyes-closed EEG data were also collected. Seven EEG microstates were extracted, and mean microstate duration and occurrence were computed.

resultsFollowing chemotherapy, there was a significant decrease in the PROMIS score (p = 0.003, d = 1.601), but no significant difference in the TMT score. Overall, microstate durations were significantly longer (p < 0.001, d = 2.837) and less evenly distributed following chemotherapy. The mean duration of microstate D (involved in attention/executive functions) significantly increased following chemotherapy (p = 0.007, d = 1.339). Comparing behavioral and microstate measures that exhibited a large effect size, no significant correlations were observed either before or after chemotherapy.

conclusionsWe observed self-reported cognitive impairment and disturbed functional dynamics in the RS brain following chemotherapy. This exploratory study provides new evidence using a within-cohort design showing that changes occur in large scale brain dynamics related to the cognitive effects of chemotherapy.

trial registrationClinicalTrials.gov identifier: NCT03277898.

Indexed as

Antineoplastic AgentsBrainBreast NeoplasmsCognitionAdultElectroencephalographyFemaleHumansMiddle AgedAntineoplastic Agentsbrain fogbreast cancercancerchemotherapycognitionEEG microstate analysiselectroencephalography (EEG)

Identifiers

PMID40038798
PMCPMC11879782

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.