Evidence map›Paper›PMID 40039455›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2024

Brainstem and Deep Gray Nuclei Modulate Brain Network Efficiency in Low-risk Term Newborns.

Venkata C Chirumamilla, Sarah B Mulkey, Tayyba Anwar, Robin Baker, G Larry Maxwell, Josepheen De Asis-Cruz, Kushal Kapse, Catherine Limperopoulos, Adre du Plessis, R B Govindan

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Venkata C Chirumamilla
Sarah B Mulkey
Tayyba Anwar
Robin Baker
G Larry Maxwell
Josepheen De Asis-Cruz
Kushal Kapse
Catherine Limperopoulos
Adre du Plessis
R B Govindan

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876
6 · The paper itself

Abstract

In low-risk term newborns, network analysis of source EEG has identified the hub regions that play an important role in information transfer in the network. However, the network efficiency changes after removing particular hub regions are not yet clear. The resting state 124channel high-density electroencephalography (HD-EEG) was collected from low-risk term newborns within 72 hours after birth. The functional connectivity (spectral coherence) matrix was built using source EEG data in the delta band. The Small-World Propensity (SWP) metric was computed after removing each hub region individually and four hubs simultaneously. In the individual analysis, the SWP was significantly reduced after removing the right caudate, left thalamus, right thalamus, and brainstem among 18 hub regions from the functional brain network (P < 0.05). A significant reduction in the SWP was observed when the same four hubs were removed simultaneously. Our data provide evidence for reduced network efficiency after removing hubs in low-risk newborns. These findings highlight the critical role of specific hubs and demonstrate diminished network efficiency after their removal in low-risk term newborns.

Indexed as

BrainBrain StemNerve NetElectroencephalographyFemaleHumansInfant, NewbornMale

Identifiers

PMID40039455
PMCPMC13014606

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.