Evidence map›Paper›PMID 40041001›Full record

ArticleHeliyon2025

Modulation of NCX1 expression in monocytes associates with multiple sclerosis progression.

Valentina Rubino, Mariarosaria Cammarota, Chiara Criscuolo, Alessandra Cianflone, Marco De Martino, Valeria de Rosa, Francesco Esposito, Gianmarco Abbadessa, Flavia Carriero, Giuseppe Terrazzano and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valentina RubinoDepartment of Medical Translational Sciences, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.
Mariarosaria CammarotaDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.
Chiara CriscuoloDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.
Alessandra CianfloneClinical and Translational Research Unit, Santobono-Pausilipon Children's Hospital, 80129, Naples, Italy.
Marco De MartinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Valeria de RosaDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.
Francesco EspositoInstitute of Experimental Endocrinology and Oncology (IEOS) "G. Salvatore", National Research Council (CNR), 80131, Naples, Italy.
Gianmarco AbbadessaDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Flavia CarrieroDepartment of Health Science, University of Basilicata, 85100, Potenza, Italy.
Giuseppe TerrazzanoDepartment of Health Science, University of Basilicata, 85100, Potenza, Italy.
Paolo ChieffiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Simona BonavitaDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Vincenzo BresciamorraDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.
Lucio AnnunziatoSDN IRCCS- Synlab SDN SpA, 80143, Naples, Italy.
Giuseppina RuggieroDepartment of Medical Translational Sciences, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.
Francesca BosciaDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, "Federico II" University of Naples, 80131, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ionic imbalance and functional heterogeneity of monocytes play key roles in multiple sclerosis (MS) progression. A better understanding of monocyte response in the context of ionic dysregulation during MS course may have relevant implications for understanding of disease pathogenesis and treatments. The sodium calcium exchanger NCX1 influences monocyte-derived macrophages reactivity under inflammation; however, little is known about its monocyte-specific expression during MS course. By means of RT-PCR, flow cytometry, and confocal analyses, we determined the expression profiling of NCX1 exchanger in monocytes of patients during relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) course. NCX1 expression was significantly upregulated in monocytes from transitional RRMS subjects. Conversely, it was significantly reduced in all monocyte subsets after RRMS conversion to SPMS. Interestingly, NCX1 levels in monocytes significantly correlated with the percentage and growth ability of the regulatory T cell (Treg) subset, whose derangement underlies MS progression. Perturbation of transcripts encoding the Ca

Indexed as

Ca2+-ATPaseClassical CD14+CD16− monocytesIntermediate CD14+CD16+ monocytesMultiple sclerosisNa+/K+-ATPaseNCX1 exchangerRRMSSPMS

Identifiers

PMID40041001
PMCPMC11876900

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.