ArticleHealth science reports2025
Specific Calcium Signal Responses in Human Keloid-Derived Fibroblasts During Cyclical Stretching: Basic Research.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Phosphoglucose isomerase directs the inflammatory response, calcium influx and fibroblast migration in keloids.Future science OA · 2026Article
- A panoramic analysis of keloid pathogenesis: multidimensional network regulation of genetics-immunity-metabolism-mechanical force.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Keloids most commonly develop in the regions where the skin is constantly stretched. Although some keloid-derived fibroblasts exhibit higher single calcium spikes than normal dermal fibroblasts during short-time cyclical stretching, the calcium signal responses to long-time stretching remain unclear. Methods: This study compared the intracellular Ca Results: No significant difference was observed between the keloid and control groups in the calcium signal response-positive rates (26.9% vs. 25.0%; Discussion: We are conducting further research based on the hypothesis that this keloid-specific subpopulation triggers the pathogenesis of keloid formation, that is, collagen overproduction, accelerated angiogenesis, and chronic inflammation.
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Registered trials
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