Evidence map›Paper›PMID 40042273›Full record

ArticlemSphere2025

The role of l-serine and l-threonine in the energy metabolism and nutritional stress response of

Mayke Bezerra Alencar, Richard Marcel Bruno Moreira Girard, Marcell Crispim, Carlos Gustavo Baptista, Marc Biran, Frederic Bringaud, Ariel Mariano Silber

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mayke Bezerra AlencarLaboratory of Biochemistry of Trypanosomatids-LaBTryps, Department of Parasitology, Institute of Biomedical Science II-ICB II, University of São Paulo-USP, São Paulo, São Paulo, Brazil.ORCID 0000-0001-9145-7994
Richard Marcel Bruno Moreira GirardLaboratory of Biochemistry of Trypanosomatids-LaBTryps, Department of Parasitology, Institute of Biomedical Science II-ICB II, University of São Paulo-USP, São Paulo, São Paulo, Brazil.
Marcell CrispimLaboratory of Biochemistry of Trypanosomatids-LaBTryps, Department of Parasitology, Institute of Biomedical Science II-ICB II, University of São Paulo-USP, São Paulo, São Paulo, Brazil.ORCID 0000-0002-2856-5471
Carlos Gustavo BaptistaLaboratory of Biochemistry of Trypanosomatids-LaBTryps, Department of Parasitology, Institute of Biomedical Science II-ICB II, University of São Paulo-USP, São Paulo, São Paulo, Brazil.
Marc BiranMicrobiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Univ. Bordeaux, CNRS, Bordeaux, France.
Frederic BringaudMicrobiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Univ. Bordeaux, CNRS, Bordeaux, France.ORCID 0000-0003-4552-6877
Ariel Mariano SilberLaboratory of Biochemistry of Trypanosomatids-LaBTryps, Department of Parasitology, Institute of Biomedical Science II-ICB II, University of São Paulo-USP, São Paulo, São Paulo, Brazil.ORCID 0000-0003-4528-4732

Funding

Agence Nationale de la Recherche (ANR) ANR-11-LABX-0024Agence Nationale de la Recherche (ANR) ANR-19-CE15-0004Agence Nationale de la Recherche (ANR) ANR-23-CE15-0040-01Centre National de la Recherche Scientifique (CNRS)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 307487/2021-0Fondation pour la Recherche Médicale (FRM) EQU201903007845Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/12938-0Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2022/16078-8
6 · The paper itself

Abstract

l-Serine and l-threonine have versatile roles in metabolism. In addition to their use in protein synthesis, these amino acids participate in the biosynthesis pathways of other amino acids and even phospholipids. Furthermore, l-serine and l-threonine can be substrates for a serine/threonine dehydratase (Ser/ThrDH), resulting in pyruvate and 2-oxobutyrate, respectively, thus being amino acids with anaplerotic potential.

Indexed as

Energy MetabolismSerineStress, PhysiologicalThreonineTrypanosoma cruziSerineThreonineamino acid metabolismbioenergeticsnutritional stresstransportTrypanosoma cruzi

Identifiers

PMID40042273
PMCPMC11934319

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.