Observational studyAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.
Observational study in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Association of 24-hour movement guideline adherence with inhibitory control in older adults: the mediating role of general self-efficacy.Frontiers in psychology · 2026Article
- Observational
- Olfactory identification impairment in cerebral small-vessel disease indicates cognitive network disconnection and predicts accelerated cognitive decline.Journal of neurology · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
introductionLate-life cognitive impairment and depression frequently co-occur and share many symptoms. However, the specific neural and clinical factors contributing to both their common and distinct profiles in older adults remain unclear.
methodsWe investigated resting-state correlates of cognitive and depressive symptoms in older adults (n = 248 and n = 95) using clinical, blood, and neuroimaging data. We computed a connectivity matrix across default mode, executive control, and salience networks. Cross-validated elastic net regression identified features reflecting cognitive function and depressive symptoms. These features were validated on a held-out dataset.
resultsWe discovered that white matter hyperintensities and nine overlapping nodes spanning all three networks are associated with both cognitive function and depressive symptoms, including left amygdala, left hippocampus, and bilateral ventral tegmental area. DISCUSSION: Our findings reveal intertwined neural nodes influencing cognitive impairment and depressive symptoms in late life, offering insights into shared characteristics and potential therapeutic targets. HIGHLIGHTS: Resting-state neuroimaging markers are associated with symptoms of cognitive decline and late-life depression. Symptom-associated connectivity alterations were present across three major brain networks of interest, including the salience, default mode, and executive control networks. Some regions of interest are associated with both cognitive function and depressive symptoms, including the left amygdala, left hippocampus, and bilateral ventral tegmental area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.