Evidence map›Paper›PMID 40042468›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Burden and care time for dementia caregivers in the LIVE@Home.Path trial.

Line Iden Berge, Renira Corinne Angeles, Marie Hidle Gedde, Stein Erik Fæø, Janne Mannseth, Maarja Vislapuu, Natalie Genevieve Søyland Puaschitz, Eirin Hillestad, Dag Aarsland, Wilco Peter Achterberg and 6 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04043364 (LIVE@Home.Path), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04043364 naunknown statusnot on this map

LIVE@Home.Path: a Mixed Method, Stepped Wedge and Randomized Controlled Trial Innovating the Clinical Pathway for Home-dwelling Persons With Dementia and Their Families

TypeinterventionalSponsorUniversity of BergenRan2019 to 2023Enrolled280ConditionsDementia, Home-dwelling, CaregiverArmsLIVE
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Burden and care time for dementia caregivers in the LIVE@Home.Path trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Line Iden BergeCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.ORCID 0000-0003-4278-5240
Renira Corinne AngelesCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Marie Hidle GeddeCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Stein Erik FæøFaculty of Health Studies, Department of Nursing, VID Specialized University, Bergen, Norway.
Janne MannsethSection for Epidemiology and Medical Statistic, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Maarja VislapuuCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Natalie Genevieve Søyland PuaschitzCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Eirin HillestadCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Dag AarslandInstitute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Wilco Peter AchterbergDepartment of Public Health and Primary Care, Center for Medicine for Older People, Leiden University Medical Center, Leiden, the Netherlands.
Heather AlloreDepartment of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Clive BallardUniversity of Exeter Medical School, Exeter, UK.
Fan LiDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
Geir SelbækNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Ipsit Vihang VahiaMcLean Hospital, Belmont, Massachusetts, USA.
Bettina Sandgate HuseboCenter for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Claude D. Pepper Older Americans Independence Center, School of Medicine, University of Maryland NIH/NIA P30AG021342Haraldsplass Deaconess HospitalNCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG021342NIA NIH HHS P30 AG066508Research Council of Norway 261605Research Council of Norway 261626Research Council of Norway 273581Yale Alzheimer's Disease Research Center NIH/NIA P30AG066508Yale Claude D. Pepper Older AmericansIndependence Center, School of Medicine, University of Maryland NIH/NIA P30AG021342
6 · The paper itself

Abstract

introductionWe investigated the effectiveness of the multicomponent learning, innovation, volunteer support, empowerment (LIVE) intervention on caregiver burden and care time in dyads of home-dwelling people with dementia and caregivers.

methodA 24 month, multicenter, stepped-wedge trial, randomized dyads to receive the 6-month LIVE intervention by municipal coordinators (May 2019 to December 2021). Primary outcomes were caregiver burden assessed by Relative Stress Scale (RSS) and informal care time spent on personal activities assessed by Resource Utilization in Dementia Personal Activities of Daily Living (RUD-PADL). Analyses used an intention-to-treat.

resultsTwo hundred eighty dyads were enrolled. Caregivers during the intervention period reported lower levels of RSS of 0.7 points (standard deviation [SD]: 0.8) compared to the caregivers in the control period. Caregivers during the intervention period reported more time spent on PADL of 11.7 hours/month (SD: 8.7) compared to caregivers during the control period; both were not statistically significant (P > 0.05). DISCUSSION: The LIVE intervention did not reduce caregiver burden or care time.

trial registrationClinicalTrials.gov NCT04043364. HIGHLIGHTS: Two hundred eighty persons with dementia and caregivers were included in a stepped wedge randomized controlled trial. We used the learning, innovation, volunteer support, empowerment (LIVE) intervention. The LIVE intervention did not reduce caregiver burden or informal care time. The LIVE intervention improved the caregiver's clinical global impression of change. Positive change was most pronounced for coordinator personalized support.

Indexed as

CaregiversCost of IllnessDementiaActivities of Daily LivingAgedAged, 80 and overFemaleHumansIndependent LivingMaleMiddle AgedStress, PsychologicalTime Factorscare coordinationcaregiver burdendementiaresource usestepped wedge randomized controlled trial

Identifiers

PMID40042468
PMCPMC11881633

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.