Reversibly Charge-Switching Polyzwitterionic/Polycationic Coatings for Biomedical Applications: Optimizing the Molecular Structure for Improved Stability.

Sophie H E Schneider, Kathrin Lehnert, Marie A Thome, Annette Kraegeloh, Karen Lienkamp

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Article in Langmuir : the ACS journal of surfaces and colloids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sophie H E SchneiderChair for Polymer Materials, Department of Materials Science & Engineering, Saarland University, Campus C4 2, Saarbrücken 66123, Germany.

Kathrin LehnertChair for Polymer Materials, Department of Materials Science & Engineering, Saarland University, Campus C4 2, Saarbrücken 66123, Germany.

Marie A ThomeChair for Polymer Materials, Department of Materials Science & Engineering, Saarland University, Campus C4 2, Saarbrücken 66123, Germany.

Annette KraegelohINM-Leibniz Institute for New Materials, Campus D2 2, Saarbrücken 66123, Germany.ORCID 0000-0001-7839-5442

Karen LienkampChair for Polymer Materials, Department of Materials Science & Engineering, Saarland University, Campus C4 2, Saarbrücken 66123, Germany.ORCID 0000-0001-6868-3707

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials that can be switched between a polycationic/antimicrobial and a polyzwitterionic/protein-repellent state have important applications, e.g., as biofilm-reducing coatings in medical devices. However, the lack of stability under storage and application conditions so far restricts the lifetime and efficiency of such materials. In this work, a polynorbornene-based polycarboxybetaine with an optimized molecular structure for improved hydrolytic stability is presented. The polymer is fully characterized on the molecular level. Surface-attached polymer networks are obtained by spin-coating and UV cross-linking. These coatings are highly uniform and demonstrate charge-switching in zeta-potential studies. Storage stability in the dry state, as well as in aqueous systems at pH 4.5 and 7.4 for 28 days, is demonstrated. At pH 8, hydrolytic degradation is observed. Overall, the materials are substantially more stable than the corresponding ester-based systems.

Identifiers

PMID40042484

DOI10.1021/acs.langmuir.4c04358

PMCPMC11924213

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LicenceCC BY

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