Evidence map›Paper›PMID 40042907›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

HCV NS3/4A protease relocalizes CCTα to viral replication sites, enhancing phosphatidylcholine synthesis and viral replication.

Shamila Sarwar, Glenn Randall

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Measles virus reprograms CD4Frontiers in cell and developmental biology · 2026
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shamila SarwarDepartment of Microbiology, The University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7703-4530
Glenn RandallDepartment of Microbiology, The University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7417-3615

Funding

Hepatitis C Virus Trafficking in HepatocytesR01AI137514 · NIAID · UNIVERSITY OF CHICAGO · PI Glenn C Randall · 2019 to 2026
$2.7M
Manipulation of lipid metabolism in (+)RNA virus replicationR01AI173337 · NIAID · UNIVERSITY OF CHICAGO · PI Glenn C Randall · 2023 to 2026
$1.6M
American Heart Association (AHA) 906530NIAID NIH HHS R01 AI137514NIAID NIH HHS R01 AI173337NIH/NIAID R01AI137514NIH/NIAID R01AI173337
6 · The paper itself

Abstract

Positive-sense single-stranded RNA [(+)RNA] viruses constitute more than one-third of all virus genera, including numerous pathogens of clinical significance. All (+)RNA viruses reorganize cellular membranes from organelles to establish replication compartments (RCs). These RCs are thought to form a platform for membrane-associated replicases, in addition to protecting the viral RNAs from cytosolic innate immune signaling and RNA-degradation machinery. Previous work demonstrated that three families of (+)RNA viruses, namely

Indexed as

Choline-Phosphate CytidylyltransferaseHepacivirusPhosphatidylcholinesSerine EndopeptidasesViral Nonstructural ProteinsVirus ReplicationDEAD-box RNA HelicasesHepatitis CHumansNucleoside-TriphosphataseSerine ProteasesViral ProteasesViral Replication CompartmentsCholine-Phosphate CytidylyltransferaseDEAD-box RNA HelicasesNS3-4A serine protease, Hepatitis C virusNS3 protein, hepatitis C virusNucleoside-TriphosphatasePhosphatidylcholinesSerine EndopeptidasesSerine ProteasesViral Nonstructural ProteinsViral Proteaseslipid synthesisviral proteasesviral replication compartments

Identifiers

PMID40042907
PMCPMC11912369

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.