Evidence map›Paper›PMID 40042971›Full record

Trial reportThe Journal of frailty & aging2025

Getting fit for hip and knee replacement: The Fit-Joints multimodal intervention for frail patients with osteoarthritis - a pilot randomized controlled trial.

Chinenye Okpara, Ahmed Negm, Jonathan Derrick Adachi, David Armstrong, Stephanie Atkinson, Victoria Avram, Justin de Beer, Genevieve Hladysh, George Ioannidis, Courtney Kennedy and 10 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of frailty & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02885337 (Fit-Joints), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02885337 nacompletednot on this map

Fit-Joints: Getting Fit for Hip or Knee Replacement, A Pilot Randomized Control Trial

TypeinterventionalSponsorMcMaster UniversityRan2016 to 2022Enrolled41ConditionsHip Osteoarthritis, Knee OsteoarthritisArmsMulti-Modal Frailty Intervention, Usual Care
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chinenye OkparaDepartment of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Ahmed NegmFaculty of Rehabilitation Science, University of Alberta, Edmonton, AB, Canada.
Jonathan Derrick AdachiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
David ArmstrongDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Stephanie AtkinsonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Victoria AvramDepartment of Surgery, Division of Orthopedic Surgery, McMaster University, Hamilton, Ontario, Canada.
Justin de BeerDepartment of Surgery, Division of Orthopedic Surgery, McMaster University, Hamilton, Ontario, Canada.
Genevieve HladyshThe YMCA of Hamilton/Burlington/Brantford, Hamilton, ON, Canada; School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
George IoannidisDepartment of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; Geras Centre for Aging Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Courtney KennedyDepartment of Medicine, McMaster University, Hamilton, ON, Canada; Geras Centre for Aging Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Patricia HewstonDepartment of Medicine, McMaster University, Hamilton, ON, Canada; School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada; Geras Centre for Aging Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Arthur LauDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Justin LeeDepartment of Medicine, McMaster University, Hamilton, ON, Canada; Geras Centre for Aging Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Julie RichardsonSchool of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Sharon MarrDepartment of Medicine, McMaster University, Hamilton, ON, Canada; Geras Centre for Aging Research, Hamilton Health Sciences, Hamilton, ON, Canada.
Akbar PanjuDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Danielle PetruccelliDepartment of Surgery, Division of Orthopedic Surgery, McMaster University, Hamilton, Ontario, Canada.
Lehana ThabaneDepartment of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada; The Research Institute of St Joseph's Healthcare, Hamilton, ON, Canada; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.
Mitchell WinemakerDepartment of Surgery, Division of Orthopedic Surgery, McMaster University, Hamilton, Ontario, Canada.
Alexandra PapaioannouDepartment of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada; The Research Institute of St Joseph's Healthcare, Hamilton, ON, Canada; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa. Electronic address: papaioannou@hhsc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlder adults with frailty have high risk for poor postoperative outcomes.

objectiveTo evaluate the feasibility of a multimodal prehabilitation program in older adults with frailty awaiting hip or knee replacement.

designParallel two-arm randomized controlled pilot trial. PARTICIPANTS AND

settingCommunity-dwelling older adults with frailty awaiting joint replacement aged ≥60 years recruited from the Musculoskeletal Central Intake and Assessment Centre (MSK CIAC), Ontario.

interventionExercise, protein and vitamin D supplements, and medication review. MEASUREMENT: Feasibility was assessed based on predefined progression criteria for recruitment, retention, data completion and adherence to intervention components. Clinical outcomes including Oxford Knee and Hip Scores, frailty index, Short Physical Performance Battery and health-related quality of life were collected at baseline, 1-week preoperative, 6-weeks and 6-months postoperative and were evaluated using generalized linear mixed models for repeated measures.

resultsA total of 69 participants were enrolled. Recruitment rate was 35 %. Participants' mean age was 74 (standard deviation (SD): 7.5); 51 % were prefrail and 36 % were frail. Participant retention was 81 %, and data completion was ≥80 %. Mean adherence to strength exercises was 4 days (95 % confidence interval (CI): 3-5 days/week), balance 3 days (95 % CI: 2-4 days/week), and flexibility 3 days (95 % CI: 3-4 days/week). Adherence to vitamin D intake was 82 % (95 % CI: 73-92 %), and medication review consultation completion was 86 % (95 % CI: 68-95 %). These outcomes met the target values for feasibility success. The Oxford Knee Score at 6-months postoperative 8.78 (95 % CI: 0.40-17.16) showed a clinically meaningful and statistically significant difference between treatment groups. There were also indications of clinically relevant changes for frailty and quality of life post-surgery.

conclusionThis trial provides strong evidence of feasibility and indications of improvements in postoperative clinical outcomes. Challenges to implementation and adherence were identified that can inform modifications to study design for future trials.

trial registrationClinicalTrials.gov NCT02885337. Registered August 31, 2016. https://classic. CLINICALTRIALS: gov/ct2/show/NCT02885337.

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeFrail ElderlyFrailtyOsteoarthritis, HipOsteoarthritis, KneeAgedAged, 80 and overExercise TherapyFeasibility StudiesFemaleHumansIndependent LivingMaleMiddle AgedOntarioVitamin DFrailtyJoint replacementOlder adultsOsteoarthritisRehabilitation

Identifiers

PMID40042971
PMCPMC12184060

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.