SynthesisNutrition reviews2025
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
Synthesis in Nutrition reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluating the Effects of Nanocurcumin Supplementation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Endocrinology, diabetes & metabolism · 2026Pooled it
- Effect of the Consumption of Species from the Zingiberaceae or Berberidaceae Family on Glycemic Profile Parameters: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Curcumin Supplementation Reduces Inflammation, Neutrophil-to-Lymphocyte Ratio (NLR), and Antioxidant Status in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.International journal of molecular sciences · 2026Trial
- Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP.Pharmaceutical biology · 2026Review
- Bioactive Constituents, Mechanisms, and Complementary Therapeutic Applications of Food-Medicine Continuum Materia Medica for Atherosclerosis Prevention and Treatment.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Therapeutic strategies for ischemic heart disease with natural product-based nanomedicines.Journal of nanobiotechnology · 2026Review
- Evaluation of the Use of Herbs, Spices, and Supplements in the Hispanic/Latino/Latina Population in Kokomo, Indiana, U.S.A.Journal of community health · 2026Article
- Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
- Curcumin Between Pleiotropic Potential and Translational Constraints.International journal of molecular sciences · 2026Review
- Synergistic protective effects of curcumin nano-emulsion and virgin coconut oil against thermal oxidation of sunflower oil and its hepatorenal toxicity in rats.Frontiers in nutrition · 2026Article
- Review
- Probiotics and Phytoantioxidants Target Coronary Endothelial Dysfunction in Irregular Sleep- and Obesity-Associated Cardiometabolic Syndrome.Life (Basel, Switzerland) · 2025Review
- Effects of Curcuminoids Plus Piperine Co-Supplementation on Liver Enzymes and Inflammation in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
contextDyslipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD), and curcumin may help improve lipid metabolism.
objectiveThis umbrella review and updated meta-analysis assessed the effects of curcumin supplementation on lipid profiles. DATA SOURCES: Electronic databases (Medline, Scopus, Cochrane, and Google Scholar) were searched through March 31, 2023, without language restrictions. DATA EXTRACTION: Two independent authors selected eligible randomized controlled trials (RCTs) involving curcumin supplementation compared with placebo, measuring total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), high-density-lipoprotein cholesterol (HDL-c), and triglyceride (TG) levels. DATA ANALYSIS: This study identified 26 systematic reviews and meta-analyses (MAs) that met the inclusion criteria for the umbrella review. Of these, 53 RCTs, with a corrected coverage area of 9.76% indicating a moderate degree of overlap, were included for re-pooling. Additionally, this study found 19 more RCTs, bringing the total number of studies for the updated MAs to 72.
resultsCurcumin significantly reduced TC, LDL-c, and TG, with mean differences (MDs) of -7.76 mg/dL (95% CI: -11.29, -4.22; I2 = 97%), -5.84 mg/dL (95% CI: -11.63, -0.05; I2 = 98%), and -13.15 mg/dL (95% CI: -17.31, -8.98; I2 = 94%), respectively, and increased HDL-c by 2.4 mg/dL (95% CI: 1.22, 3.57; I2 = 94%). The reductions in LDL-c and TG reached the minimally clinically important differences (MCIDs). However, the reduction in TC and increase in HDL-c did not meet their respective MCIDs. Subgroup analysis showed greater lipid improvements in patients with metabolic-related diseases, particularly type 2 diabetes. Enhanced bioavailability forms of curcumin, supplementation for at least 8 weeks, and exercise yielded additional benefits.
conclusionThe study confirmed that curcumin has an anti-lipidemic effect on patients with noncommunicable diseases. A form of curcumin with enhanced bioavailability is preferred, and supplementation for at least 8 weeks, along with exercise, may be used as an accessible approach to reduce the risk of ASCVD. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42023415577.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.